PGE2: Opposite effect on catecholamine release from phaeochromocytoma and adrenal medulla

Y. Gutman; P. Boonyaviroj

doi:10.1016/0090-6980(76)90029-0

PGE₂: Opposite effect on catecholamine release from phaeochromocytoma and adrenal medulla

Y. Gutman^*
, P. Boonyaviroj

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The effect of PGE₂ on catecholamine release from human adrenal medulla and phaechromocytoma was studied in slices incubated in vitro. In each of 3 normal human adrenal medullae PGE₂ (10^-7 M) caused a significant inhibition of the release of catecholamines in in vitro incubation. In each of 3 phaeochromocytomas studied PGE₂(10^-7 M) caused a significant increase of catecholamine release in in-vitro incubation. The possible relevance of this mechanism to the regulation of catecholamine release in phaeochromocytoma is discussed.

Original language	English
Pages (from-to)	487-491
Number of pages	5
Journal	Prostaglandins
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/0090-6980(76)90029-0
State	Published - Oct 1976

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abstract = "The effect of PGE2 on catecholamine release from human adrenal medulla and phaechromocytoma was studied in slices incubated in vitro. In each of 3 normal human adrenal medullae PGE2 (10-7 M) caused a significant inhibition of the release of catecholamines in in vitro incubation. In each of 3 phaeochromocytomas studied PGE2(10-7 M) caused a significant increase of catecholamine release in in-vitro incubation. The possible relevance of this mechanism to the regulation of catecholamine release in phaeochromocytoma is discussed.",

author = "Y. Gutman and P. Boonyaviroj",

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AB - The effect of PGE2 on catecholamine release from human adrenal medulla and phaechromocytoma was studied in slices incubated in vitro. In each of 3 normal human adrenal medullae PGE2 (10-7 M) caused a significant inhibition of the release of catecholamines in in vitro incubation. In each of 3 phaeochromocytomas studied PGE2(10-7 M) caused a significant increase of catecholamine release in in-vitro incubation. The possible relevance of this mechanism to the regulation of catecholamine release in phaeochromocytoma is discussed.

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PGE₂: Opposite effect on catecholamine release from phaeochromocytoma and adrenal medulla

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