TY - JOUR
T1 - Phage therapy
T2 - A new horizon in the antibacterial treatment of oral pathogens
AU - Shlezinger, Mor
AU - Khalifa, Leron
AU - Houri-Haddad, Yael
AU - Coppenhagen-Glazer, Shunit
AU - Resch, Grégory
AU - Que, Yok Ai
AU - Beyth, Shaul
AU - Dorfman, Elisheva
AU - Hazan, Ronen
AU - Beyth, Nurit
N1 - Publisher Copyright:
© 2017 Bentham Science Publishers.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Dental diseases are perhaps the most prevalent infection-related diseases in humans. Biofilm is involved in almost every infectious disease compromising oral health, notably caries, periodontal disease, gingivitis, endodontic infections and peri-implantitis. Current therapies of biofilm-derived oral infections lack sensitivity; they are not species-specific and kill pathogenic species as well as commensal species, which are protective against the formation of pathogenic biofilms. Moreover, antibiotics have a limited effect on biofilm and are almost unused in oral diseases. A promising alternative approach is bacteriophage (phage) therapy. Phages play a key role in the natural balance in a predator-prey relationship with bacteria and thus have the potential to be efficient anti-bacterial agents. Phages are highly efficient against biofilm, strain specific and easy to isolate and manipulate. Thus, like in many other medicinal fields, phage therapy offers new horizons to dentistry, both therapeutics and research. The present review presents the etiology of common oral diseases, characterization of the infection and the treatment challenges of phage therapy in dentistry. Recent findings and development in the use of phages for prevention, control, and treatment of oral infections as well as possibilities of engineering the oral microbiome are discussed.
AB - Dental diseases are perhaps the most prevalent infection-related diseases in humans. Biofilm is involved in almost every infectious disease compromising oral health, notably caries, periodontal disease, gingivitis, endodontic infections and peri-implantitis. Current therapies of biofilm-derived oral infections lack sensitivity; they are not species-specific and kill pathogenic species as well as commensal species, which are protective against the formation of pathogenic biofilms. Moreover, antibiotics have a limited effect on biofilm and are almost unused in oral diseases. A promising alternative approach is bacteriophage (phage) therapy. Phages play a key role in the natural balance in a predator-prey relationship with bacteria and thus have the potential to be efficient anti-bacterial agents. Phages are highly efficient against biofilm, strain specific and easy to isolate and manipulate. Thus, like in many other medicinal fields, phage therapy offers new horizons to dentistry, both therapeutics and research. The present review presents the etiology of common oral diseases, characterization of the infection and the treatment challenges of phage therapy in dentistry. Recent findings and development in the use of phages for prevention, control, and treatment of oral infections as well as possibilities of engineering the oral microbiome are discussed.
KW - Antibiotic resistance
KW - Bacteriophage
KW - Biofilm
KW - Caries
KW - Dentistry
KW - Multi drug resistant bacteria
KW - Oral
KW - Periodontal disease
KW - Phage
KW - Phage therapy
UR - http://www.scopus.com/inward/record.url?scp=85015656329&partnerID=8YFLogxK
U2 - 10.2174/1568026616666160930145649
DO - 10.2174/1568026616666160930145649
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C2 - 27770768
AN - SCOPUS:85015656329
SN - 1568-0266
VL - 17
SP - 1199
EP - 1211
JO - Current Topics in Medicinal Chemistry
JF - Current Topics in Medicinal Chemistry
IS - 10
ER -