Irrigation with treate wastewater (TWW) an application of biosolis introuce numerous pharmaceutical an personal care proucts (PPCPs) into agro-foo systems. While the use of TWW an biosolis has many societal benefits, introuction of PPCPs in prouction agriculture poses potential foo safety an human health risks. A comprehensive risk assessment an management scheme of PPCPs in agro-foo systems is limite by multiple factors, not least the sheer number of investigate compouns an their iverse structures. Here we follow the fate of PPCPs in the water-soil-prouce continuum by consiering processes an variables that influence PPCP transfer an accumulation. By analyzing the steps in the soil-plant-human iet nexus, we propose a tiere framework as a path forwar to prioritize PPCPs that coul have a high potential for plant accumulation an thus pose greatest risk. This article examines research progress to ate an current research challenges, highlighting the potential value of leveraging existing knowlege from ecaes of research on other chemicals such as pesticies. A process-riven scheme is outline to erive a short list that may be use to refocus our future research efforts on PPCPs an other analogous emerging contaminants in agro-foo systems.
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