TY - JOUR
T1 - Pharmaceutical Implications of Sex-Related RNA Divergence in Psychiatric Disorders
AU - Simchovitz-Gesher, Alon
AU - Soreq, Hermona
N1 - Publisher Copyright:
© 2020 The Authors
PY - 2020/11
Y1 - 2020/11
N2 - Male–female differences have long been observed in the epidemiology and clinical presentation of psychiatric disorders. Current understanding is based on sex hormones and on transcription patterns governed by the sex chromosomes, and specific sexually dimorphic pathways were only recently identified. However, the underlying molecular mechanisms and pharmaceutical implications remain unclear. We highlight the importance of studying the sex-specific patterns of mental diseases at all levels from genomics to pharmaceutics. In particular, we discuss transcriptional level differences between the sexes in psychiatric disorders and outline the possible impact of such research on future pharmaceutical developments.
AB - Male–female differences have long been observed in the epidemiology and clinical presentation of psychiatric disorders. Current understanding is based on sex hormones and on transcription patterns governed by the sex chromosomes, and specific sexually dimorphic pathways were only recently identified. However, the underlying molecular mechanisms and pharmaceutical implications remain unclear. We highlight the importance of studying the sex-specific patterns of mental diseases at all levels from genomics to pharmaceutics. In particular, we discuss transcriptional level differences between the sexes in psychiatric disorders and outline the possible impact of such research on future pharmaceutical developments.
KW - cholinergic network
KW - noncoding RNAs
KW - pharmaceutics
KW - psychiatric disorders
UR - http://www.scopus.com/inward/record.url?scp=85092185915&partnerID=8YFLogxK
U2 - 10.1016/j.tips.2020.09.003
DO - 10.1016/j.tips.2020.09.003
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C2 - 33012545
AN - SCOPUS:85092185915
SN - 0165-6147
VL - 41
SP - 840
EP - 850
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 11
ER -