Abstract
1. Five new sustained‐release dosage forms of valproic acid (VPA) were developed. 2. The new sustained‐release formulations were administered to six healthy subjects for comparison with a standard tablet and an i.v. preparation of the drug. 3. Three of the formulations exhibited a more prolonged and uniform absorption rate and yielded more sustained serum levels after ingestion. These three formulations maintained serum therapeutic levels of VPA for 24 h after a single oral administration of 1 g, and were bioequivalent to a marketed standard tablet of VPA. 4. The absorption profile of the various oral formulations was analysed pharmacokinetically, using the Loo‐Riegelman procedure.
Original language | English |
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Pages (from-to) | 401-411 |
Number of pages | 11 |
Journal | Biopharmaceutics and Drug Disposition |
Volume | 6 |
Issue number | 4 |
DOIs | |
State | Published - 1985 |
Keywords
- Pharmacokinetics
- Sustained‐release dosage forms
- Valproic acid