Pharmacokinetic profile of conjugated verrucarol urinary metabolites in dogs

The pharmacokinetics and renal excretion of a trichothecene mycotoxin, verrucarol, were studied in six mongrel dogs following IV administration (0.4 mg kg⁻¹). The fraction of verrucarol excreted intact in the urine ranged from 0.9% to 2.7% of the administered dose. The fraction of verrucarol metabolites excreted in the urine was 32–60% for verrucaryl glucuronides and 32–47% for verrucaryl sulphates. These urinary conjugated metabolites were analyzed quantitatively following their enzymatic hydrolysis. The half‐life of verrucarol calculated from the urinary data of its conjugated metabolites was not significantly different from the half‐life calculated from the plasma data of the parent compound.