Pharmacokinetics and pharmacodynamics of trans-endometrial administered peptides and macromolecules

A. Huffman; I. Shaked; A. Avramoff; G. Golomb

doi:10.1016/0169-409X(95)00087-N

Pharmacokinetics and pharmacodynamics of trans-endometrial administered peptides and macromolecules

A. Huffman^*, I. Shaked, A. Avramoff, G. Golomb

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The pharmacokinetic considerations that are unique to the intrauterine (IU) route of macromolecule administration are discussed, and specific examples of macromolecules with high (insulin) and low (dextran 70 000 and polyethylene glycol 4000) absorption rates, following IU administration in rats are addressed. The pharmacodynamic aspects of IU administration are also discussed with specific focus on the differences between the continuous mode of peptide administration in contrast to the pulsatile mode and on counter-regulation by feedback mechanisms in the body. These issues are demonstrated by specific examples of the kinetics of action of calcitonin, erythropoietin and insulin following IU administration in rats.

Original language	English
Pages (from-to)	191-203
Number of pages	13
Journal	Advanced Drug Delivery Reviews
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/0169-409X(95)00087-N
State	Published - 15 Nov 1995

Keywords

Bioavailability
Calcitonin
Concentration-effect relationship
Drug absorption
Erythropoietin
Input function
Insulin
Intrauterine administration
Polyethylene glycol
dextran

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10.1016/0169-409X(95)00087-N

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title = "Pharmacokinetics and pharmacodynamics of trans-endometrial administered peptides and macromolecules",

abstract = "The pharmacokinetic considerations that are unique to the intrauterine (IU) route of macromolecule administration are discussed, and specific examples of macromolecules with high (insulin) and low (dextran 70 000 and polyethylene glycol 4000) absorption rates, following IU administration in rats are addressed. The pharmacodynamic aspects of IU administration are also discussed with specific focus on the differences between the continuous mode of peptide administration in contrast to the pulsatile mode and on counter-regulation by feedback mechanisms in the body. These issues are demonstrated by specific examples of the kinetics of action of calcitonin, erythropoietin and insulin following IU administration in rats.",

keywords = "Bioavailability, Calcitonin, Concentration-effect relationship, Drug absorption, Erythropoietin, Input function, Insulin, Intrauterine administration, Polyethylene glycol, dextran",

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T1 - Pharmacokinetics and pharmacodynamics of trans-endometrial administered peptides and macromolecules

AU - Huffman, A.

AU - Shaked, I.

AU - Avramoff, A.

AU - Golomb, G.

PY - 1995/11/15

Y1 - 1995/11/15

N2 - The pharmacokinetic considerations that are unique to the intrauterine (IU) route of macromolecule administration are discussed, and specific examples of macromolecules with high (insulin) and low (dextran 70 000 and polyethylene glycol 4000) absorption rates, following IU administration in rats are addressed. The pharmacodynamic aspects of IU administration are also discussed with specific focus on the differences between the continuous mode of peptide administration in contrast to the pulsatile mode and on counter-regulation by feedback mechanisms in the body. These issues are demonstrated by specific examples of the kinetics of action of calcitonin, erythropoietin and insulin following IU administration in rats.

AB - The pharmacokinetic considerations that are unique to the intrauterine (IU) route of macromolecule administration are discussed, and specific examples of macromolecules with high (insulin) and low (dextran 70 000 and polyethylene glycol 4000) absorption rates, following IU administration in rats are addressed. The pharmacodynamic aspects of IU administration are also discussed with specific focus on the differences between the continuous mode of peptide administration in contrast to the pulsatile mode and on counter-regulation by feedback mechanisms in the body. These issues are demonstrated by specific examples of the kinetics of action of calcitonin, erythropoietin and insulin following IU administration in rats.

KW - Bioavailability

KW - Calcitonin

KW - Concentration-effect relationship

KW - Drug absorption

KW - Erythropoietin

KW - Input function

KW - Insulin

KW - Intrauterine administration

KW - Polyethylene glycol

KW - dextran

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JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

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Pharmacokinetics and pharmacodynamics of trans-endometrial administered peptides and macromolecules

Abstract

Keywords

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