Pharmacokinetics of ampicillin administered intravenously and intraosseously to kittens

R. Goldstein*, E. Lavy, M. Shem-Tov, G. Glickman, H. Bark, G. Ziv

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


An aqueous solution of ampicillin sodium (100 mg ml-1) was administered intravenously and intraosseously to six kitten at 50 mg kg-1 in a crossover study. Jugular vein blood samples were taken at intervals up to eight hours after treatment and the serum ampicillin concentration-time data, derived from a microbiological assay, were analysed pharmacokinetically. The disposition kinetics of ampicillin administered by the two routes were very similar. The mean elimination half-life (t i 2β), the area-derived volume of distribution (Varea) and the total body clearance (ClB) values after the intravenous and intraosseous treatment were 86·3 and 79·0 minutes, 0·9 and 0·8 litre kg-1 and 7·3 and 7·6 ml min -1 kg-1, respectively. No side-effects related to the intraosseous administration of the drug were observed.

Original languageAmerican English
Pages (from-to)186-187
Number of pages2
JournalResearch in Veterinary Science
Issue number2
StatePublished - Sep 1995


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