TY - JOUR
T1 - Pharmacokinetics of ampicillin administered intravenously and intraosseously to kittens
AU - Goldstein, R.
AU - Lavy, E.
AU - Shem-Tov, M.
AU - Glickman, G.
AU - Bark, H.
AU - Ziv, G.
PY - 1995/9
Y1 - 1995/9
N2 - An aqueous solution of ampicillin sodium (100 mg ml-1) was administered intravenously and intraosseously to six kitten at 50 mg kg-1 in a crossover study. Jugular vein blood samples were taken at intervals up to eight hours after treatment and the serum ampicillin concentration-time data, derived from a microbiological assay, were analysed pharmacokinetically. The disposition kinetics of ampicillin administered by the two routes were very similar. The mean elimination half-life (t i 2β), the area-derived volume of distribution (Varea) and the total body clearance (ClB) values after the intravenous and intraosseous treatment were 86·3 and 79·0 minutes, 0·9 and 0·8 litre kg-1 and 7·3 and 7·6 ml min -1 kg-1, respectively. No side-effects related to the intraosseous administration of the drug were observed.
AB - An aqueous solution of ampicillin sodium (100 mg ml-1) was administered intravenously and intraosseously to six kitten at 50 mg kg-1 in a crossover study. Jugular vein blood samples were taken at intervals up to eight hours after treatment and the serum ampicillin concentration-time data, derived from a microbiological assay, were analysed pharmacokinetically. The disposition kinetics of ampicillin administered by the two routes were very similar. The mean elimination half-life (t i 2β), the area-derived volume of distribution (Varea) and the total body clearance (ClB) values after the intravenous and intraosseous treatment were 86·3 and 79·0 minutes, 0·9 and 0·8 litre kg-1 and 7·3 and 7·6 ml min -1 kg-1, respectively. No side-effects related to the intraosseous administration of the drug were observed.
UR - http://www.scopus.com/inward/record.url?scp=0029085407&partnerID=8YFLogxK
U2 - 10.1016/0034-5288(95)90059-4
DO - 10.1016/0034-5288(95)90059-4
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C2 - 8525114
AN - SCOPUS:0029085407
SN - 0034-5288
VL - 59
SP - 186
EP - 187
JO - Research in Veterinary Science
JF - Research in Veterinary Science
IS - 2
ER -