Pharmacokinetics of urinary metabolites of cannabidiol in the dog

Emil Samara, Meir Bialer*, David J. Harvey

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

The pharmacokinetics of cannabidiol (CBD) and six of its urinary metabolites was investigated in dogs. CBD was administered intravenously to three dogs, and urine was collected at specified time intervals over a period of 30h. The apparent terminal half‐life of CBD calculated from the slope of the sigma minus plot was significantly shorter (2h) than the half‐life of CBD calculated from plasma data (8h), and the apparent terminal half‐life of the metabolites was similar to that of the CBD calculated from plasma data, indicating that the elimination of these metabolites was formation rate limited. The time course of the metabolite excretion could be divided into two phases: the first phase contained mainly monohydroxy metabolites, and the second phase contained mainly metabolites with a carboxylic acid moiety in their side‐chain.

Original languageEnglish
Pages (from-to)785-795
Number of pages11
JournalBiopharmaceutics and Drug Disposition
Volume11
Issue number9
DOIs
StatePublished - Dec 1990

Keywords

  • Cannabidiol
  • Cannabidiol urinary metabolites
  • Pharmacokinetics

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