TY - JOUR
T1 - Pharmacokinetics of urinary metabolites of cannabidiol in the dog
AU - Samara, Emil
AU - Bialer, Meir
AU - Harvey, David J.
PY - 1990/12
Y1 - 1990/12
N2 - The pharmacokinetics of cannabidiol (CBD) and six of its urinary metabolites was investigated in dogs. CBD was administered intravenously to three dogs, and urine was collected at specified time intervals over a period of 30h. The apparent terminal half‐life of CBD calculated from the slope of the sigma minus plot was significantly shorter (2h) than the half‐life of CBD calculated from plasma data (8h), and the apparent terminal half‐life of the metabolites was similar to that of the CBD calculated from plasma data, indicating that the elimination of these metabolites was formation rate limited. The time course of the metabolite excretion could be divided into two phases: the first phase contained mainly monohydroxy metabolites, and the second phase contained mainly metabolites with a carboxylic acid moiety in their side‐chain.
AB - The pharmacokinetics of cannabidiol (CBD) and six of its urinary metabolites was investigated in dogs. CBD was administered intravenously to three dogs, and urine was collected at specified time intervals over a period of 30h. The apparent terminal half‐life of CBD calculated from the slope of the sigma minus plot was significantly shorter (2h) than the half‐life of CBD calculated from plasma data (8h), and the apparent terminal half‐life of the metabolites was similar to that of the CBD calculated from plasma data, indicating that the elimination of these metabolites was formation rate limited. The time course of the metabolite excretion could be divided into two phases: the first phase contained mainly monohydroxy metabolites, and the second phase contained mainly metabolites with a carboxylic acid moiety in their side‐chain.
KW - Cannabidiol
KW - Cannabidiol urinary metabolites
KW - Pharmacokinetics
UR - http://www.scopus.com/inward/record.url?scp=0025642492&partnerID=8YFLogxK
U2 - 10.1002/bdd.2510110906
DO - 10.1002/bdd.2510110906
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C2 - 2271754
AN - SCOPUS:0025642492
SN - 0142-2782
VL - 11
SP - 785
EP - 795
JO - Biopharmaceutics and Drug Disposition
JF - Biopharmaceutics and Drug Disposition
IS - 9
ER -