Phase-Specific Microstimulation Differentially Modulates Beta Oscillations and Affects Behavior

Oren Peles; Uri Werner-Reiss; Hagai Bergman; Zvi Israel; Eilon Vaadia

doi:10.1016/j.celrep.2020.02.005

Phase-Specific Microstimulation Differentially Modulates Beta Oscillations and Affects Behavior

Oren Peles^*, Uri Werner-Reiss, Hagai Bergman, Zvi Israel, Eilon Vaadia

^*Corresponding author for this work

Edmond & Lily Safra Center for Brain Sciences

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

It is widely accepted that Beta-band oscillations play a role in sensorimotor behavior. To further explore this role, we developed a hybrid platform to combine neural operant conditioning and phase-specific intracortical microstimulation (ICMS). We trained monkeys, implanted with 96 electrode arrays in the motor cortex, to volitionally enhance local field potential (LFP) Beta-band (20–30 Hz) activity at selected sites using a brain-machine interface. We find that Beta oscillations of LFP and single-unit spiking activity increase dramatically with brain-machine interface training and that pre-movement Beta power is anti-correlated with task performance. We also find that phase-specific ICMS modulates the power and phase of oscillations, shifting local networks between oscillatory and non-oscillatory states. Furthermore, ICMS induces phase-dependent effects in animal reaction times and success rates. These findings contribute to unraveling the functional role of cortical oscillations and to the future development of clinical tools for ameliorating abnormal neuronal activities in brain disease.

Original language	American English
Pages (from-to)	2555-2566.e3
Journal	Cell Reports
Volume	30
Issue number	8
DOIs	https://doi.org/10.1016/j.celrep.2020.02.005
State	Published - 25 Feb 2020

Bibliographical note

Funding Information:
The authors would like to thank A. Shapochnikov and S. Freeman for their technical assistance; M. Doron for programming; B. Engelhard and A. Globerson for their help in planning the experiments; and I. Nelken, M. London, R. Paz, and D. Hansel for their helpful comments. This study was supported in part by the Israeli Ministry of Defense ( MAFAT ), the Rosetrees Trust , the Gatsby Charitable Foundation , the Adelis Foundation , and the Jack H. Skirball Chair and Research Fund in Brain Research . O.P. was supported by the Goren-Khazzam Scholarship .

Publisher Copyright:
© 2020 The Authors

Keywords

Beta oscillations
brain-machine interface
local field potential
microsimulation
motor cortex
non-human primates
operant conditioning

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10.1016/j.celrep.2020.02.005

Cite this

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title = "Phase-Specific Microstimulation Differentially Modulates Beta Oscillations and Affects Behavior",

abstract = "It is widely accepted that Beta-band oscillations play a role in sensorimotor behavior. To further explore this role, we developed a hybrid platform to combine neural operant conditioning and phase-specific intracortical microstimulation (ICMS). We trained monkeys, implanted with 96 electrode arrays in the motor cortex, to volitionally enhance local field potential (LFP) Beta-band (20–30 Hz) activity at selected sites using a brain-machine interface. We find that Beta oscillations of LFP and single-unit spiking activity increase dramatically with brain-machine interface training and that pre-movement Beta power is anti-correlated with task performance. We also find that phase-specific ICMS modulates the power and phase of oscillations, shifting local networks between oscillatory and non-oscillatory states. Furthermore, ICMS induces phase-dependent effects in animal reaction times and success rates. These findings contribute to unraveling the functional role of cortical oscillations and to the future development of clinical tools for ameliorating abnormal neuronal activities in brain disease.",

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author = "Oren Peles and Uri Werner-Reiss and Hagai Bergman and Zvi Israel and Eilon Vaadia",

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N2 - It is widely accepted that Beta-band oscillations play a role in sensorimotor behavior. To further explore this role, we developed a hybrid platform to combine neural operant conditioning and phase-specific intracortical microstimulation (ICMS). We trained monkeys, implanted with 96 electrode arrays in the motor cortex, to volitionally enhance local field potential (LFP) Beta-band (20–30 Hz) activity at selected sites using a brain-machine interface. We find that Beta oscillations of LFP and single-unit spiking activity increase dramatically with brain-machine interface training and that pre-movement Beta power is anti-correlated with task performance. We also find that phase-specific ICMS modulates the power and phase of oscillations, shifting local networks between oscillatory and non-oscillatory states. Furthermore, ICMS induces phase-dependent effects in animal reaction times and success rates. These findings contribute to unraveling the functional role of cortical oscillations and to the future development of clinical tools for ameliorating abnormal neuronal activities in brain disease.

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Phase-Specific Microstimulation Differentially Modulates Beta Oscillations and Affects Behavior

Abstract

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Keywords

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