Phase-Specific Microstimulation Differentially Modulates Beta Oscillations and Affects Behavior

Oren Peles*, Uri Werner-Reiss, Hagai Bergman, Zvi Israel, Eilon Vaadia

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

It is widely accepted that Beta-band oscillations play a role in sensorimotor behavior. To further explore this role, we developed a hybrid platform to combine neural operant conditioning and phase-specific intracortical microstimulation (ICMS). We trained monkeys, implanted with 96 electrode arrays in the motor cortex, to volitionally enhance local field potential (LFP) Beta-band (20–30 Hz) activity at selected sites using a brain-machine interface. We find that Beta oscillations of LFP and single-unit spiking activity increase dramatically with brain-machine interface training and that pre-movement Beta power is anti-correlated with task performance. We also find that phase-specific ICMS modulates the power and phase of oscillations, shifting local networks between oscillatory and non-oscillatory states. Furthermore, ICMS induces phase-dependent effects in animal reaction times and success rates. These findings contribute to unraveling the functional role of cortical oscillations and to the future development of clinical tools for ameliorating abnormal neuronal activities in brain disease.

Original languageAmerican English
Pages (from-to)2555-2566.e3
JournalCell Reports
Volume30
Issue number8
DOIs
StatePublished - 25 Feb 2020

Bibliographical note

Publisher Copyright:
© 2020 The Authors

Keywords

  • Beta oscillations
  • brain-machine interface
  • local field potential
  • microsimulation
  • motor cortex
  • non-human primates
  • operant conditioning

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