Phase transfer catalysis in N‐alkylation of the pharmaceutical intermediates phenothiazine and 2‐chlorophenothiazine

Igal Gozlan*, David Ladkani, Mark Halpern, Mordecai Rabinovitz, David Avnir

*Corresponding author for this work

Research output: Contribution to journalComment/debate

14 Scopus citations

Abstract

The N‐alkylation of the two title compounds was studied, utilizing phase transfer catalysis (PTC) methods. Very mild reaction conditions were developed, especially for three‐carbon N‐alkylation. Of special interest is the high‐yield synthesis of N‐(3‐chloropropyl)‐2‐chlorophenothiazine. The results are discussed in terms of the classical PTC/OH mechanisms.

Original languageEnglish
Pages (from-to)613-614
Number of pages2
JournalJournal of Heterocyclic Chemistry
Volume21
Issue number2
DOIs
StatePublished - 1984
Externally publishedYes

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