Phase transfer catalysis in N‐alkylation of the pharmaceutical intermediates phenothiazine and 2‐chlorophenothiazine

Igal Gozlan; David Ladkani; Mark Halpern; Mordecai Rabinovitz; David Avnir

doi:10.1002/jhet.5570210271

Phase transfer catalysis in N‐alkylation of the pharmaceutical intermediates phenothiazine and 2‐chlorophenothiazine

Igal Gozlan^*
, David Ladkani
, Mark Halpern
, Mordecai Rabinovitz
, David Avnir

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate

14 Scopus citations

Abstract

The N‐alkylation of the two title compounds was studied, utilizing phase transfer catalysis (PTC) methods. Very mild reaction conditions were developed, especially for three‐carbon N‐alkylation. Of special interest is the high‐yield synthesis of N‐(3‐chloropropyl)‐2‐chlorophenothiazine. The results are discussed in terms of the classical PTC/OH⁻ mechanisms.

Original language	English
Pages (from-to)	613-614
Number of pages	2
Journal	Journal of Heterocyclic Chemistry
Volume	21
Issue number	2
DOIs	https://doi.org/10.1002/jhet.5570210271
State	Published - 1984
Externally published	Yes

Access to Document

10.1002/jhet.5570210271

Cite this

@article{6642e993602c4b83a91afc10897a4274,

title = "Phase transfer catalysis in N‐alkylation of the pharmaceutical intermediates phenothiazine and 2‐chlorophenothiazine",

abstract = "The N‐alkylation of the two title compounds was studied, utilizing phase transfer catalysis (PTC) methods. Very mild reaction conditions were developed, especially for three‐carbon N‐alkylation. Of special interest is the high‐yield synthesis of N‐(3‐chloropropyl)‐2‐chlorophenothiazine. The results are discussed in terms of the classical PTC/OH− mechanisms.",

author = "Igal Gozlan and David Ladkani and Mark Halpern and Mordecai Rabinovitz and David Avnir",

year = "1984",

doi = "10.1002/jhet.5570210271",

language = "אנגלית",

volume = "21",

pages = "613--614",

journal = "Journal of Heterocyclic Chemistry",

issn = "0022-152X",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

TY - JOUR

T1 - Phase transfer catalysis in N‐alkylation of the pharmaceutical intermediates phenothiazine and 2‐chlorophenothiazine

AU - Gozlan, Igal

AU - Ladkani, David

AU - Halpern, Mark

AU - Rabinovitz, Mordecai

AU - Avnir, David

PY - 1984

Y1 - 1984

N2 - The N‐alkylation of the two title compounds was studied, utilizing phase transfer catalysis (PTC) methods. Very mild reaction conditions were developed, especially for three‐carbon N‐alkylation. Of special interest is the high‐yield synthesis of N‐(3‐chloropropyl)‐2‐chlorophenothiazine. The results are discussed in terms of the classical PTC/OH− mechanisms.

AB - The N‐alkylation of the two title compounds was studied, utilizing phase transfer catalysis (PTC) methods. Very mild reaction conditions were developed, especially for three‐carbon N‐alkylation. Of special interest is the high‐yield synthesis of N‐(3‐chloropropyl)‐2‐chlorophenothiazine. The results are discussed in terms of the classical PTC/OH− mechanisms.

UR - https://www.scopus.com/pages/publications/0021183541

U2 - 10.1002/jhet.5570210271

DO - 10.1002/jhet.5570210271

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.comment???

AN - SCOPUS:0021183541

SN - 0022-152X

VL - 21

SP - 613

EP - 614

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

IS - 2

ER -

Phase transfer catalysis in N‐alkylation of the pharmaceutical intermediates phenothiazine and 2‐chlorophenothiazine

Abstract

Access to Document

Other files and links

Fingerprint

Cite this