Phosphatidylserine in the outer leaflet of red blood cells from β‐thalassemia patients may explain the chronic hypercoagulable state and thrombotic episodes

Vered Borenstain‐Ben Yashar, Yechezkel Barenholz*, Esther Hy‐Am, Eliezer A. Rachmilewitz, Amiram Eldor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

150 Scopus citations

Abstract

Investigation of red blood cells from β‐thalassemia patients by means of prothrombinase assay reveals phosphatidylserine in the outer leaflet of the plasma membrane. This might explain their elevated susceptibility to phagocytosis by macrophages and the chronic hypercoagulable state, frequent thrombotic events, and life‐long platelet activation that are found in thalassemic patients. © 1993 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)63-65
Number of pages3
JournalAmerican Journal of Hematology
Volume44
Issue number1
DOIs
StatePublished - Sep 1993

Keywords

  • membrane asymmetry
  • prothrombinase assay
  • red blood cells
  • β‐thalassemia

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