Phosphatidylserine in the outer leaflet of red blood cells from β‐thalassemia patients may explain the chronic hypercoagulable state and thrombotic episodes

Vered Borenstain‐Ben Yashar; Yechezkel Barenholz; Esther Hy‐Am; Eliezer A. Rachmilewitz; Amiram Eldor

doi:10.1002/ajh.2830440114

Phosphatidylserine in the outer leaflet of red blood cells from β‐thalassemia patients may explain the chronic hypercoagulable state and thrombotic episodes

Vered Borenstain‐Ben Yashar
, Yechezkel Barenholz^*
, Esther Hy‐Am
, Eliezer A. Rachmilewitz
, Amiram Eldor

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

155 Scopus citations

Abstract

Investigation of red blood cells from β‐thalassemia patients by means of prothrombinase assay reveals phosphatidylserine in the outer leaflet of the plasma membrane. This might explain their elevated susceptibility to phagocytosis by macrophages and the chronic hypercoagulable state, frequent thrombotic events, and life‐long platelet activation that are found in thalassemic patients. © 1993 Wiley‐Liss, Inc.

Original language	English
Pages (from-to)	63-65
Number of pages	3
Journal	American Journal of Hematology
Volume	44
Issue number	1
DOIs	https://doi.org/10.1002/ajh.2830440114
State	Published - Sep 1993

Keywords

membrane asymmetry
prothrombinase assay
red blood cells
β‐thalassemia

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title = "Phosphatidylserine in the outer leaflet of red blood cells from β‐thalassemia patients may explain the chronic hypercoagulable state and thrombotic episodes",

abstract = "Investigation of red blood cells from β‐thalassemia patients by means of prothrombinase assay reveals phosphatidylserine in the outer leaflet of the plasma membrane. This might explain their elevated susceptibility to phagocytosis by macrophages and the chronic hypercoagulable state, frequent thrombotic events, and life‐long platelet activation that are found in thalassemic patients. {\textcopyright} 1993 Wiley‐Liss, Inc.",

keywords = "membrane asymmetry, prothrombinase assay, red blood cells, β‐thalassemia",

author = "Yashar, \{Vered Borenstain‐Ben\} and Yechezkel Barenholz and Esther Hy‐Am and Rachmilewitz, \{Eliezer A.\} and Amiram Eldor",

year = "1993",

month = sep,

doi = "10.1002/ajh.2830440114",

language = "אנגלית",

volume = "44",

pages = "63--65",

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Phosphatidylserine in the outer leaflet of red blood cells from β‐thalassemia patients may explain the chronic hypercoagulable state and thrombotic episodes. / Yashar, Vered Borenstain‐Ben; Barenholz, Yechezkel; Hy‐Am, Esther et al.
In: American Journal of Hematology, Vol. 44, No. 1, 09.1993, p. 63-65.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Phosphatidylserine in the outer leaflet of red blood cells from β‐thalassemia patients may explain the chronic hypercoagulable state and thrombotic episodes

AU - Yashar, Vered Borenstain‐Ben

AU - Barenholz, Yechezkel

AU - Hy‐Am, Esther

AU - Rachmilewitz, Eliezer A.

AU - Eldor, Amiram

PY - 1993/9

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N2 - Investigation of red blood cells from β‐thalassemia patients by means of prothrombinase assay reveals phosphatidylserine in the outer leaflet of the plasma membrane. This might explain their elevated susceptibility to phagocytosis by macrophages and the chronic hypercoagulable state, frequent thrombotic events, and life‐long platelet activation that are found in thalassemic patients. © 1993 Wiley‐Liss, Inc.

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KW - membrane asymmetry

KW - prothrombinase assay

KW - red blood cells

KW - β‐thalassemia

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Phosphatidylserine in the outer leaflet of red blood cells from β‐thalassemia patients may explain the chronic hypercoagulable state and thrombotic episodes

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