Phospholipid patterns of erythrocytes in schizophrenia: Relationships to symptomatology

A. M. Ponizovsky*, I. Modai, Y. Nechamkin, G. Barshtein, M. S. Ritsner, S. Yedgar, S. Lecht, L. D. Bergelson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The phospholipid composition of red blood cells (RBC) from 32 haloperidol-treated schizophrenic patients, classified according to the positive and negative syndrome scale (PANSS) as showing either predominantly positive or predominantly negative symptoms, was determined and compared with that of normal controls. While the levels of phosphatidylcholine and phosphatidylserine were similar in all three groups, sphingomyelin (SM) and phosphatidylethanolamine (PE) were, respectively, increased and decreased in RBCs of schizophrenic patients. In both patient groups, the SM/PE ratios correlated directly with the PANSS negative symptom scale scores and inversely with the positive symptom scale scores. However, the inverse changes in the contents of SM and PE were much more expressed in the negative group. It is suggested that a main source of that difference is a higher activity of the polyunsaturated acid-selective phospholipase A2 in the negative syndrome patients than in the positive syndrome and control groups.

Original languageAmerican English
Pages (from-to)121-126
Number of pages6
JournalSchizophrenia Research
Issue number1-2
StatePublished - 1 Oct 2001

Bibliographical note

Funding Information:
This work was supported by grants from The Szold Foundation (Keren Yissumit of the Hebrew University, to S. Yedgar and G. Barshtein) and The Israel Ministry of Health (No. 4165, to G. Barshtein).


  • Phosphatidylethanolamine
  • Positive and negative syndromes
  • Schizophrenia
  • Sphingomyelin


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