TY - JOUR
T1 - Phosphonoacetic acid-resistant mutants of herpes simplex virus
T2 - effect of phosphonoacetic acid on virus replication and in vitro deoxyribonucleic acid synthesis in isolated nuclei
AU - Becker, Y.
AU - Asher, Y.
AU - Cohen, Y.
AU - Weinberg-Zahlering, E.
AU - Shlomai, J.
PY - 1977
Y1 - 1977
N2 - Phosphonoacetic acid (PAA) inhibits the replication of herpes simplex virus in BSC-1 cells and the in vitro synthesis of deoxyribonucleic acid (DNA) in isolated nuclei. Phosphonopropionic acid at a concentration of 100 μg/ml had no effect on herpes simplex virus replication. PAA-resistant mutants were obtained at a rate of 1 in 104 plaque-forming units after 5-bromodeoxyuridine mutagenization of the virus. These mutants replicate in BSC-1 cells in the presence of 100 μg of PAA per ml and induce a PAA-resistant DNA polymerase that synthesizes DNA in vitro in the presence of PAA.
AB - Phosphonoacetic acid (PAA) inhibits the replication of herpes simplex virus in BSC-1 cells and the in vitro synthesis of deoxyribonucleic acid (DNA) in isolated nuclei. Phosphonopropionic acid at a concentration of 100 μg/ml had no effect on herpes simplex virus replication. PAA-resistant mutants were obtained at a rate of 1 in 104 plaque-forming units after 5-bromodeoxyuridine mutagenization of the virus. These mutants replicate in BSC-1 cells in the presence of 100 μg of PAA per ml and induce a PAA-resistant DNA polymerase that synthesizes DNA in vitro in the presence of PAA.
UR - https://www.scopus.com/pages/publications/0017685267
U2 - 10.1128/AAC.11.5.919
DO - 10.1128/AAC.11.5.919
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0017685267
SN - 0066-4804
VL - 11
SP - 919
EP - 922
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 5
ER -