Photobiomodulation alleviates Burning Mouth Syndrome pain: Immediate and weekly outcomes explored

Ori Finfter, Layla Kizel, Rakefet Czerninski, Shimrit Heiliczer*, Yair Sharav, Rafael Cohen, Doron J. Aframian, Yaron Haviv*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review


    Burning Mouth Syndrome (BMS) is an intraoral chronic burning or dysesthetic sensation, without clinically evident causative lesions on clinical examination and investigation. Aim: To assess immediate and weekly effects of photobiomodulation (PBM) on BMS patients. Methods: Thirty BMS patients were treated intra-orally with photobiomodulation 940(±10) nm (InGaAsP) 3 W, semi-conductor diode, weekly, for up to 10 weeks. Pain intensity, measured using the Visual Analogue Scale (VAS), and characteristics were recorded immidiately after each treatment, along with a weekly average VAS. Results: Immediate mean VAS score decreased from a starting score of 7.80 ± 1.83 to 2.07 ± 2.55 (p < 0.001). The mean weekly VAS score for the week after the final treatment session was higher (5.73 ± 2.80, p < 0.001) than the immediate response, but still significantly lower than the starting score (p = 0.017). We observed a trend of pain improvement with more treatments, but this was only statistically significant up to the third treatment. Male gender and unilateral pain correlated with better PBM efficacy (p = 0.017, 0.022, respectively). Conclusion: PBM provides significant immediate pain relief for BMS patients after each treatment; however, the efficacy decreases notably over the following week. A trend of increasing pain relief across treatments was observed, statistically significant up to the third treatment.

    Original languageAmerican English
    JournalOral Diseases
    StateAccepted/In press - 2024

    Bibliographical note

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    © 2024 Wiley Periodicals LLC.


    • BMS
    • long-term laser therapy
    • photobiomodulation
    • short-term laser therapy


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