Photocatalytic reactive oxygen species formation by semiconductor-metal hybrid nanoparticles. Toward light-induced modulation of biological processes

Nir Waiskopf; Yuval Ben-Shahar; Michael Galchenko; Inbal Carmel; Gilli Moshitzky; Hermona Soreq; Uri Banin

doi:10.1021/acs.nanolett.6b01298

Photocatalytic reactive oxygen species formation by semiconductor-metal hybrid nanoparticles. Toward light-induced modulation of biological processes

Nir Waiskopf, Yuval Ben-Shahar, Michael Galchenko, Inbal Carmel, Gilli Moshitzky, Hermona Soreq, Uri Banin^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

Semiconductor-metal hybrid nanoparticles manifest efficient light-induced spatial charge separation at the semiconductor-metal interface, as demonstrated by their use for hydrogen generation via water splitting. Here, we pioneer a study of their functionality as efficient photocatalysts for the formation of reactive oxygen species. We observed enhanced photocatalytic activity forming hydrogen peroxide, superoxide, and hydroxyl radicals upon light excitation, which was significantly larger than that of the semiconductor nanocrystals, attributed to the charge separation and the catalytic function of the metal tip. We used this photocatalytic functionality for modulating the enzymatic activity of horseradish peroxidase as a model system, demonstrating the potential use of hybrid nanoparticles as active agents for controlling biological processes through illumination. The capability to produce reactive oxygen species by illumination on-demand enhances the available peroxidase-based tools for research and opens the path for studying biological processes at high spatiotemporal resolution, laying the foundation for developing novel therapeutic approaches.

Original language	American English
Pages (from-to)	4266-4273
Number of pages	8
Journal	Nano Letters
Volume	16
Issue number	7
DOIs	https://doi.org/10.1021/acs.nanolett.6b01298
State	Published - 13 Jul 2016

Bibliographical note

Funding Information:
We thank Professor Dorit Ben-Shachar's lab from the department of psychiatry, B. Rappaport Faculty of Medicine, Technion, Rambam Health Care Campus, Haifa for assistance in the oxygen consumption measurements. The research leading to these results has received funding from The Israel Science Foundation (Grant 1560/13). U.B. thanks the Alfred and Erica Larisch memorial chair. H.S. acknowledges support by The Israel Science Foundation (Grant 817/13) and the Edmond and Lily Safra Center of Brain Science. N.W acknowledges support by a Clara Robert Einstein Scholarship. Y.B.S. acknowledges support by the Ministry of Science, Technology, and Space, Israel and The Camber Scholarship.

Publisher Copyright:
© 2016 American Chemical Society.

Keywords

Semiconductor-metal hybrid nanoparticles
peroxidase
photocatalysis
reactive oxygen species

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acs.nanolett.6b01298

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abstract = "Semiconductor-metal hybrid nanoparticles manifest efficient light-induced spatial charge separation at the semiconductor-metal interface, as demonstrated by their use for hydrogen generation via water splitting. Here, we pioneer a study of their functionality as efficient photocatalysts for the formation of reactive oxygen species. We observed enhanced photocatalytic activity forming hydrogen peroxide, superoxide, and hydroxyl radicals upon light excitation, which was significantly larger than that of the semiconductor nanocrystals, attributed to the charge separation and the catalytic function of the metal tip. We used this photocatalytic functionality for modulating the enzymatic activity of horseradish peroxidase as a model system, demonstrating the potential use of hybrid nanoparticles as active agents for controlling biological processes through illumination. The capability to produce reactive oxygen species by illumination on-demand enhances the available peroxidase-based tools for research and opens the path for studying biological processes at high spatiotemporal resolution, laying the foundation for developing novel therapeutic approaches.",

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author = "Nir Waiskopf and Yuval Ben-Shahar and Michael Galchenko and Inbal Carmel and Gilli Moshitzky and Hermona Soreq and Uri Banin",

note = "Funding Information: We thank Professor Dorit Ben-Shachar's lab from the department of psychiatry, B. Rappaport Faculty of Medicine, Technion, Rambam Health Care Campus, Haifa for assistance in the oxygen consumption measurements. The research leading to these results has received funding from The Israel Science Foundation (Grant 1560/13). U.B. thanks the Alfred and Erica Larisch memorial chair. H.S. acknowledges support by The Israel Science Foundation (Grant 817/13) and the Edmond and Lily Safra Center of Brain Science. N.W acknowledges support by a Clara Robert Einstein Scholarship. Y.B.S. acknowledges support by the Ministry of Science, Technology, and Space, Israel and The Camber Scholarship. Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

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AB - Semiconductor-metal hybrid nanoparticles manifest efficient light-induced spatial charge separation at the semiconductor-metal interface, as demonstrated by their use for hydrogen generation via water splitting. Here, we pioneer a study of their functionality as efficient photocatalysts for the formation of reactive oxygen species. We observed enhanced photocatalytic activity forming hydrogen peroxide, superoxide, and hydroxyl radicals upon light excitation, which was significantly larger than that of the semiconductor nanocrystals, attributed to the charge separation and the catalytic function of the metal tip. We used this photocatalytic functionality for modulating the enzymatic activity of horseradish peroxidase as a model system, demonstrating the potential use of hybrid nanoparticles as active agents for controlling biological processes through illumination. The capability to produce reactive oxygen species by illumination on-demand enhances the available peroxidase-based tools for research and opens the path for studying biological processes at high spatiotemporal resolution, laying the foundation for developing novel therapeutic approaches.

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Photocatalytic reactive oxygen species formation by semiconductor-metal hybrid nanoparticles. Toward light-induced modulation of biological processes

Abstract

Bibliographical note

Keywords

UN SDGs

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