Photodeprotection of up to Eight Photolabile Protecting Groups from a Single Glycan

Mamidi Samarasimhareddy, Israel Alshanski, Evgeniy Mervinetsky, Mattan Hurevich*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Permanent protecting groups are essential for oligosaccharide synthesis. However, the removal of the traditionally used protecting groups is not trivial and demands considerable expertise. Using photolabile protecting groups as permanent protection for glycan can overcome many limitations associated with the traditional oligosaccharide synthesis approach. It is demonstrated here that up to eight photolabile protecting groups can be readily removed from a single glycan using a benchtop LED setup that is very easy to operate. This report suggests that further development of the strategy will offer an attractive alternative for oligosaccharide synthesis.

Original languageAmerican English
Article numberst-2017-b0896-l
Pages (from-to)880-884
Number of pages5
JournalSynlett
Volume29
Issue number7
DOIs
StatePublished - 23 Apr 2018

Bibliographical note

Publisher Copyright:
© Georg Thieme Verlag Stuttgart - New York.

Keywords

  • carbohydrates
  • glycosylation
  • oligosaccharides
  • photochemistry
  • photolabile protecting groups

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