Physical properties of gold nanoparticles affect skin penetration via hair follicles

Nethanel Friedman*, Arie Dagan, Jhonathan Elia, Sharon Merims, Ofra Benny

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Drug penetration through the skin is significant for both transdermal and dermal delivery. One mechanism that has attracted attention over the last two decades is the transport pathway of nanoparticles via hair follicle, through the epidermis, directly to the pilosebaceous unit and blood vessels. Studies demonstrate that particle size is an important factor for drug penetration. However, in order to gain more information for the purpose of improving this mode of drug delivery, a thorough understanding of the optimal physical particle properties is needed. In this study, we fabricated fluorescently labeled gold nanoparticles (GNP) with a tight control over the size and shape. The effect of the particles' physical parameters on follicular penetration was evaluated histologically. We used horizontal human skin sections and found that the optimal size for polymeric particles is 0.25 μm. In addition, shape penetration experiments revealed gold nanostars' superiority over spherical particles. Our findings suggest the importance of the particles' physical properties in the design of nanocarriers delivered to the pilosebaceous unit.

Original languageAmerican English
Article number102414
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume36
DOIs
StatePublished - Aug 2021

Bibliographical note

Funding Information:
The Harvey M. Krueger Family Center for Nanoscience and Nanotechnology of the Hebrew University is acknowledged. The project was funded by a Kamin fund of the Israel Innovation Authority Israel Innovation Authority (grant agreement no. 68721), the Israel Science Foundation (ISF) grant (grant agreement no. 0394883) and the European Research Council (ERC-StG) under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 0305260). We thank Ms. Winni Fejne, an honorary member of The Hebrew University Board, for contributing to the student scholarship.

Funding Information:
The Harvey M. Krueger Family Center for Nanoscience and Nanotechnology of the Hebrew University is acknowledged. The project was funded by a Kamin fund of the Israel Innovation AuthorityIsrael Innovation Authority (grant agreement no. 68721), the Israel Science Foundation (ISF) grant (grant agreement no. 0394883) and the European Research Council (ERC-StG) under the European Union's Horizon 2020 research and innovation program (grant agreement no. 0305260). We thank Ms. Winni Fejne, an honorary member of The Hebrew University Board, for contributing to the student scholarship.

Publisher Copyright:
© 2021 The Authors

Keywords

  • Au nanoparticle
  • Dermal delivery
  • Gold nanoparticles
  • Hair follicle

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