Physiology and pathophysiology of the basal ganglia-thalamo-cortical networks

Boris Rosin, Alon Nevet, Shlomo Elias, Michal Rivlin-Etzion, Zvi Israel, Hagai Bergman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Low-frequency resting tremor is one of the cardinal signs of Parkinson's disease (PD) and occurs also in some of its animal models. Current physiological studies and models of the basal ganglia indicate that changes of discharge pattern and synchronization of basal ganglia neurons rather than modification in their discharge rate are crucial to the pathophysiology of PD. However, parkinsonian tremor is not strictly correlated with the synchronous oscillations in the basal ganglia networks. We therefore suggest that abnormal basal ganglia output enforces abnormal thalamo-cortical processing leading to akinesia, the main negative symptom of Parkinson's disease. The parkinsonian positive motor signs, such as tremor and rigidity, most likely evolve as a downstream compensatory mechanism.

Original languageAmerican English
Pages (from-to)S437-S439
JournalParkinsonism and Related Disorders
Volume13
Issue numberSUPPL. 3
DOIs
StatePublished - 2007

Bibliographical note

Funding Information:
This study was partly supported by a Hebrew University Netherlands Association (HUNA) grant entitled “Fighting against Parkinson”. The study sponsors had no involvement in any aspect of the study.

Keywords

  • MPTP
  • Oscillations
  • Parkinson's disease
  • Primates
  • Synchronization
  • Tremor

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