Pinning NF-κB to the Nucleus

Yinon Ben-Neriah

doi:10.1016/S1097-2765(03)00493-3

Pinning NF-κB to the Nucleus

Yinon Ben-Neriah^*

^*Corresponding author for this work

Department of Immunology and Cancer Research

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The peptidyl-prolyl isomerase Pin1 binds and stabilizes several phosphorylated transcription and mitosis regulators via its WW interacting domain. It is overexpressed in breast tumors and, as Ryo et al. (2003b) discuss in this issue of Molecular Cell, could account for their constitutive nuclear NF-κB expression. The proposed mechanism involves protection of Pin1-bound p65 against SOCS-1-mediated ubiquitination.

Original language	English
Pages (from-to)	1344-1345
Number of pages	2
Journal	Molecular Cell
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/S1097-2765(03)00493-3
State	Published - Dec 2003

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10.1016/S1097-2765(03)00493-3

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abstract = "The peptidyl-prolyl isomerase Pin1 binds and stabilizes several phosphorylated transcription and mitosis regulators via its WW interacting domain. It is overexpressed in breast tumors and, as Ryo et al. (2003b) discuss in this issue of Molecular Cell, could account for their constitutive nuclear NF-κB expression. The proposed mechanism involves protection of Pin1-bound p65 against SOCS-1-mediated ubiquitination.",

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Pinning NF-κB to the Nucleus

Abstract

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