Pinning NF-κB to the Nucleus

Yinon Ben-Neriah*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


The peptidyl-prolyl isomerase Pin1 binds and stabilizes several phosphorylated transcription and mitosis regulators via its WW interacting domain. It is overexpressed in breast tumors and, as Ryo et al. (2003b) discuss in this issue of Molecular Cell, could account for their constitutive nuclear NF-κB expression. The proposed mechanism involves protection of Pin1-bound p65 against SOCS-1-mediated ubiquitination.

Original languageAmerican English
Pages (from-to)1344-1345
Number of pages2
JournalMolecular Cell
Issue number6
StatePublished - Dec 2003


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