Pitfalls in Anfinsen's thermodynamic hypothesis

Arieh Ben-Naim

doi:10.1016/j.cplett.2011.05.049

Pitfalls in Anfinsen's thermodynamic hypothesis

Arieh Ben-Naim^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A few pitfalls associated with the Anfinsen's thermodynamic hypothesis are discussed. The most profound one is the misinterpretation of the Anfinsen 'thermodynamic hypothesis' in terms of the Second Law of Thermodynamics. This misinterpretation has inspired many scientists to search for a global-minimum in the Gibbs energy as a function of the conformation of the protein, sometimes referred to as the Gibbs energy landscape. Such a minimum in the Gibbs energy is different from the minimum required by the Second Law of Thermodynamics.

Original language	English
Pages (from-to)	126-128
Number of pages	3
Journal	Chemical Physics Letters
Volume	511
Issue number	1-3
DOIs	https://doi.org/10.1016/j.cplett.2011.05.049
State	Published - 26 Jul 2011

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Pitfalls in Anfinsen's thermodynamic hypothesis

Abstract

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