Abstract
The reproductive function and sexual maturation is under the control of the hypothalamic-pituitary-gonadal axis. The gonadotropins, LH (luteinizing hormone) and FSH (follicle-stimulating hormone), are the two hormones secreted by gonadotropes cells located in the anterior pituitary, that control gonadal steroidogenesis and gametogenesis in all mammals. Practically, LH stimulates the Leydig cells of the testes to produce testosterone (and indirectly estradiol), whereas FSH stimulates the spermatogenic tissue of the testes, thus insuring proper male reproductive function. This article aims at providing an overview of knowledge regarding the properties and regulatory mechanism that exist within the pituitary gonadotropic system in animal models. Particularly, we will focus on understanding how a single cell type can guarantee appropriate regulation of both LH and FSH using a unique ligand.
| Original language | English |
|---|---|
| Title of host publication | Encyclopedia of Reproduction |
| Subtitle of host publication | Volume 1-6, Second Edition |
| Publisher | Elsevier |
| Pages | 184-187 |
| Number of pages | 4 |
| Volume | 1 |
| ISBN (Electronic) | 9780128118993 |
| ISBN (Print) | 9780128151457 |
| DOIs | |
| State | Published - 1 Jan 2018 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2018 Elsevier Inc. All rights reserved.
Keywords
- Calcium signaling
- Follicle-stimulating hormone
- Gonadotropes
- Gonadotropins
- Luteinizing hormone
- Pituitary
- Pulsatility
- Reproduction
- Transcriptional regulation
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