Plasma exchange as treatment for lawsone (henna) intoxication

Deborah Rund*, Tova Schaap, Nael Da'as, Dina Ben Yehuda, Joseph Kalish

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Lawsone (2-hydroxy-1,4-naphthoquinone) is the active ingredient of Lawsonia alba, whose crushed leaves are known as henna, used as a hair and skin dye in many parts of the world. Accidental or deliberate ingestion of Lawsone has a high mortality rate (up to 31%) owing to rhabdomyolysis and renal failure. The authors report the first successful use of plasmapheresis as an adjunct to the treatment of these symptoms in a 69-year-old man who suffered severe symptoms of Lawsone poisoning due to inadvertent ingestion. Although most cases reported in the literature have been treated using supportive techniques, including hemodialysis, the high mortality despite these measures suggests that prompt plasma exchange may be a lifesaving technique for this syndrome.

Original languageAmerican English
Pages (from-to)243-245
Number of pages3
JournalJournal of Clinical Apheresis
Volume22
Issue number4
DOIs
StatePublished - 2007
Externally publishedYes

Keywords

  • Hemolysis
  • Henna
  • Lawsone
  • Plasmapheresis
  • Toxicology

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