Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study

Amy Moore, Hagit Hochner, Colleen M. Sitlani, Michelle A. Williams, Andrew N. Hoofnagle, Ian H. De Boer, Bryan Kestenbaum, David S. Siscovick, Yechiel Friedlander, Daniel A. Enquobahrie*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Objective To examine cross-sectional relationships between plasma vitamin D and cardiometabolic risk factors in young adults. Design Data were collected from interviews, physical examinations and biomarker measurements. Total plasma 25-hydroxyvitamin D (25(OH)D) was measured using LC-tandem MS. Associations between 25(OH)D and cardiometabolic risk factors were modelled using weighted linear regression with robust estimates of standard errors. Setting Individuals born in Jerusalem during 1974-1976. Subjects Participants of the Jerusalem Perinatal Study (n 1204) interviewed and examined at age 32 years. Participants were oversampled for low and high birth weight and for maternal pre-pregnancy obesity. Results Mean total 25(OH)D concentration among participants was 21·7 (sd 8·9) ng/ml. Among males, 25(OH)D was associated with homeostatic model assessment of insulin resistance (natural log-transformed, β=-0·011, P=0·004) after adjustment for BMI. However, these associations were not present among females (P for sex interaction=0·005). Conclusions We found evidence for inverse associations of 25(OH)D with markers of insulin resistance among males, but not females, in a healthy, young adult Caucasian population. Prospective studies and studies conducted on other populations investigating sex-specific effects of vitamin D on cardiometabolic risk factors are warranted.

Original languageAmerican English
Pages (from-to)1324-1331
Number of pages8
JournalPublic Health Nutrition
Volume18
Issue number7
DOIs
StatePublished - 10 Feb 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 The Authors.

Keywords

  • Cardiometabolic risk
  • HOMA-IR
  • Vitamin D

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