Plasma volume regulation in rodents. Comparison of heat and dehydration effects

M. Horowitz, A. Borut

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Rats may be representative of animals unable to regulate well their blood fluid volume under adverse environmental conditions because of the inability to control protein movement precisely enough between vascular and extravascular spaces. Such imbalance happens upon exposure to heat stress, and is more pronounced in thermal dehydration. Man and the cat probably belong to this category. Spiny mice may serve as a model for animals with better control over their blood fluid volume because they possess a more responsive and versatile system for blood protein partitioning. In thermal stress (heat treatment) greater protein outflux was measured but no change in relative blood volume was noted. In contrast, animals in severe thermal dehydration responded with decreased capillary permeability and reduced protein movement, with the same end result.

Original languageEnglish
Pages (from-to)864-867
Number of pages4
JournalIsrael Journal of Medical Sciences
Volume12
Issue number8
StatePublished - 1976

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