Plasmid-mediated qnrB2 and carbapenemase gene blaKPC-2 carried on the same plasmid in carbapenem-resistant ciprofloxacin-susceptible Enterobacter cloacae isolates

Inna Chmelnitsky; Shiri Navon-Venezia; Jacob Strahilevitz; Yehuda Carmeli

doi:10.1128/AAC.01341-07

Plasmid-mediated qnrB2 and carbapenemase gene bla_KPC-2 carried on the same plasmid in carbapenem-resistant ciprofloxacin-susceptible Enterobacter cloacae isolates

Inna Chmelnitsky, Shiri Navon-Venezia, Jacob Strahilevitz, Yehuda Carmeli^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Fourteen out of 16 carbapenem-resistant quinolone-susceptible Enterobacter cloacae isolates were found to carry qnrB2 and bla_KPC-2 genes encoded on the same plasmid. One isolate also carried the aac(6′)-Ib-cr gene. Coexistence of quinolone resistance determinants and bla_KPC-2 on the same plasmid in quinolone-susceptible E. cloacae isolates may have important clinical implications.

Original language	American English
Pages (from-to)	2962-2965
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	52
Issue number	8
DOIs	https://doi.org/10.1128/AAC.01341-07
State	Published - Aug 2008
Externally published	Yes

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10.1128/AAC.01341-07

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title = "Plasmid-mediated qnrB2 and carbapenemase gene blaKPC-2 carried on the same plasmid in carbapenem-resistant ciprofloxacin-susceptible Enterobacter cloacae isolates",

abstract = "Fourteen out of 16 carbapenem-resistant quinolone-susceptible Enterobacter cloacae isolates were found to carry qnrB2 and blaKPC-2 genes encoded on the same plasmid. One isolate also carried the aac(6′)-Ib-cr gene. Coexistence of quinolone resistance determinants and blaKPC-2 on the same plasmid in quinolone-susceptible E. cloacae isolates may have important clinical implications.",

author = "Inna Chmelnitsky and Shiri Navon-Venezia and Jacob Strahilevitz and Yehuda Carmeli",

year = "2008",

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language = "American English",

volume = "52",

pages = "2962--2965",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

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Plasmid-mediated qnrB2 and carbapenemase gene bla_KPC-2 carried on the same plasmid in carbapenem-resistant ciprofloxacin-susceptible Enterobacter cloacae isolates. / Chmelnitsky, Inna; Navon-Venezia, Shiri; Strahilevitz, Jacob et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 52, No. 8, 08.2008, p. 2962-2965.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Plasmid-mediated qnrB2 and carbapenemase gene blaKPC-2 carried on the same plasmid in carbapenem-resistant ciprofloxacin-susceptible Enterobacter cloacae isolates

AU - Chmelnitsky, Inna

AU - Navon-Venezia, Shiri

AU - Strahilevitz, Jacob

AU - Carmeli, Yehuda

PY - 2008/8

Y1 - 2008/8

N2 - Fourteen out of 16 carbapenem-resistant quinolone-susceptible Enterobacter cloacae isolates were found to carry qnrB2 and blaKPC-2 genes encoded on the same plasmid. One isolate also carried the aac(6′)-Ib-cr gene. Coexistence of quinolone resistance determinants and blaKPC-2 on the same plasmid in quinolone-susceptible E. cloacae isolates may have important clinical implications.

AB - Fourteen out of 16 carbapenem-resistant quinolone-susceptible Enterobacter cloacae isolates were found to carry qnrB2 and blaKPC-2 genes encoded on the same plasmid. One isolate also carried the aac(6′)-Ib-cr gene. Coexistence of quinolone resistance determinants and blaKPC-2 on the same plasmid in quinolone-susceptible E. cloacae isolates may have important clinical implications.

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DO - 10.1128/AAC.01341-07

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JO - Antimicrobial Agents and Chemotherapy

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ER -

Plasmid-mediated qnrB2 and carbapenemase gene bla_KPC-2 carried on the same plasmid in carbapenem-resistant ciprofloxacin-susceptible Enterobacter cloacae isolates

Abstract

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