Plasticity and biological diversity of myeloid derived suppressor cells

Kerem Ben-Meir, Nira Twaik, Michal Baniyash

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

Myeloid derived suppressor cells (MDSCs) are immature myeloid cells characterized by diverse phenotypes and functions. They impair effector functions of immune cells and promote tumor growth, angiogenesis, and tissue damage. In pathologies characterized by chronic inflammation, MDSCs are arrested in their immature state and migrate from the bone marrow to the periphery and to the site of inflammation, where they mediate immunosuppression. When reaching new environments, which exhibit a different array of cytokines, chemokines, and pro-inflammatory mediators, MDSCs sense and adapt to the altered micro-environment by virtue of acquiring different suppressive features/functions that involve changing their cell fate, surface receptors, metabolism and intracellular as well as secreted molecules. This review summarizes some of the latest publications highlighting various layers of MDSC plasticity in relation to different pathologies. We discuss treatments capitalizing on MDSC plasticity aimed at combating MDSCs or manipulating their suppressive activity for improved therapy.

Original languageAmerican English
Pages (from-to)154-161
Number of pages8
JournalCurrent Opinion in Immunology
Volume51
DOIs
StatePublished - Apr 2018

Bibliographical note

Funding Information:
The authors gratefully acknowledge the support of the Society of Research Associates of the Lautenberg Center and the Harold B Abramson Chair in Immunology. This work was supported by the Israel Science Foundation , the joint program between the Israel Science Foundation and the National Natural Science Foundation of China , the Israeli Ministry of Health , the Joint German-Israeli Research Program , the Israel Cancer Research Fund , the NOFAR Program of the Academic Research Office of the Chief Scientist , Ministry of Economy , the Melanoma Research Alliance Funds and the Joseph and Matilda Melnick Funds . The authors thank Hadas Ashkenazi-Preiser, Yaron Meirow, Leonor Daniel, Andrea Simona Safir and Eitan Yefe-Nof for reading and commenting on the manuscript.

Publisher Copyright:
© 2018 Elsevier Ltd

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