Plasticity beyond cancer cells and the immunosuppressive switch

Zvi Granot*, Zvi G. Fridlender

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations

Abstract

Tumor initiation, growth, and metastatic progression are complex processes that, in order to be successful, require extraordinary cellular plasticity. Accordingly, tumor cell plasticity and how it affects disease progression have been studied extensively. However, as our understanding of the tumor microenvironment deepens, we are confronted with the notion that functional plasticity in the context of cancer is not limited to tumor cells alone but is also commonly seen in normal stromal cells of the microenvironment, and specifically in immune cells. Here, we review the functional plasticity these cells exhibit in the context of cancer, highlighting the role of circulating and tumor-associated neutrophils. We further discuss how this plasticity supports or limits tumor progression, inducing an "immunosuppressive switch" to promote further tumor growth and development.

Original languageAmerican English
Pages (from-to)4441-4445
Number of pages5
JournalCancer Research
Volume75
Issue number21
DOIs
StatePublished - 1 Nov 2015

Bibliographical note

Publisher Copyright:
© 2015 AACR.

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