TY - JOUR
T1 - Plasticizers in the manufacture of novel skin-bioadhesive patches
AU - Gal, Avi
AU - Nussinovitch, Amos
PY - 2009/3/31
Y1 - 2009/3/31
N2 - The effects of plasticizer inclusion (10%, w/w) on roughness, mechanical and adhesive properties of novel skin-bioadhesive patches produced from polyvinyl alcohol and polyvinyl pyrrolidone were studied. Dry, non-adhesive patches became adhesive upon wetting. Roughness profiles of the patches and a skin model were studied, by measuring average values of Ra (recognized as average roughness in practice) and Rz (average of the vertical distances from the highest peak to the lowest valley within five equal sampling lengths). These values ranged from 2.4 to 3.8 μm and from 10.9 to 12.5 μm, respectively. Plasticizers had no significant effect on them. The average Ra obtained for the skin model was six- to eightfold higher than that obtained for the patches. Plasticizer inclusion caused a reduction in patch tensile strength and an increase in its strain at failure-the lower the plasticizer's molecular weight, the greater its effect. Plasticizer inclusion also caused a significant reduction in peeling force: 1.5 ± 0.11 and 2.8 ± 0.13 g force/cm for patches with and without glycerol, respectively. Patch adhesion to the skin also depended on the time elapsed between application and removal. In summary, plasticizer inclusion widened the range of mechanical and adhesive properties of the patches.
AB - The effects of plasticizer inclusion (10%, w/w) on roughness, mechanical and adhesive properties of novel skin-bioadhesive patches produced from polyvinyl alcohol and polyvinyl pyrrolidone were studied. Dry, non-adhesive patches became adhesive upon wetting. Roughness profiles of the patches and a skin model were studied, by measuring average values of Ra (recognized as average roughness in practice) and Rz (average of the vertical distances from the highest peak to the lowest valley within five equal sampling lengths). These values ranged from 2.4 to 3.8 μm and from 10.9 to 12.5 μm, respectively. Plasticizers had no significant effect on them. The average Ra obtained for the skin model was six- to eightfold higher than that obtained for the patches. Plasticizer inclusion caused a reduction in patch tensile strength and an increase in its strain at failure-the lower the plasticizer's molecular weight, the greater its effect. Plasticizer inclusion also caused a significant reduction in peeling force: 1.5 ± 0.11 and 2.8 ± 0.13 g force/cm for patches with and without glycerol, respectively. Patch adhesion to the skin also depended on the time elapsed between application and removal. In summary, plasticizer inclusion widened the range of mechanical and adhesive properties of the patches.
KW - Adhesion
KW - Mechanical properties
KW - Peeling
KW - Plasticizer
KW - Roughness
UR - http://www.scopus.com/inward/record.url?scp=61349200805&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2008.11.015
DO - 10.1016/j.ijpharm.2008.11.015
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 19073242
AN - SCOPUS:61349200805
SN - 0378-5173
VL - 370
SP - 103
EP - 109
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -