Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions

Ezequiel Wexselblatt, Eylon Yavin, Dan Gibson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

Losing ligands rapidly: PtIV complexes with haloacetato ligands can hydrolyze rapidly under biological conditions (pH7 and 37 °C, see scheme) and the rate increases with increasing pH value. Possible mechanisms for this hydrolysis are examined using H218O and ESI-MS analysis.

Original languageAmerican English
Pages (from-to)6059-6062
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number23
DOIs
StatePublished - 3 Jun 2013

Keywords

  • haloacetato ligands
  • hydrolysis
  • platinum
  • prodrugs

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