Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions

Ezequiel Wexselblatt; Eylon Yavin; Dan Gibson

doi:10.1002/anie.201300640

Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions

Ezequiel Wexselblatt, Eylon Yavin, Dan Gibson^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Losing ligands rapidly: Pt^IV complexes with haloacetato ligands can hydrolyze rapidly under biological conditions (pH7 and 37 °C, see scheme) and the rate increases with increasing pH value. Possible mechanisms for this hydrolysis are examined using H₂¹⁸O and ESI-MS analysis.

Original language	English
Pages (from-to)	6059-6062
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	23
DOIs	https://doi.org/10.1002/anie.201300640
State	Published - 3 Jun 2013

Keywords

haloacetato ligands
hydrolysis
platinum
prodrugs

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10.1002/anie.201300640

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title = "Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions",

abstract = "Losing ligands rapidly: PtIV complexes with haloacetato ligands can hydrolyze rapidly under biological conditions (pH7 and 37 °C, see scheme) and the rate increases with increasing pH value. Possible mechanisms for this hydrolysis are examined using H218O and ESI-MS analysis.",

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author = "Ezequiel Wexselblatt and Eylon Yavin and Dan Gibson",

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AU - Wexselblatt, Ezequiel

AU - Yavin, Eylon

AU - Gibson, Dan

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Y1 - 2013/6/3

N2 - Losing ligands rapidly: PtIV complexes with haloacetato ligands can hydrolyze rapidly under biological conditions (pH7 and 37 °C, see scheme) and the rate increases with increasing pH value. Possible mechanisms for this hydrolysis are examined using H218O and ESI-MS analysis.

AB - Losing ligands rapidly: PtIV complexes with haloacetato ligands can hydrolyze rapidly under biological conditions (pH7 and 37 °C, see scheme) and the rate increases with increasing pH value. Possible mechanisms for this hydrolysis are examined using H218O and ESI-MS analysis.

KW - haloacetato ligands

KW - hydrolysis

KW - platinum

KW - prodrugs

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JF - Angewandte Chemie - International Edition

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ER -

Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions

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