Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions

Ezequiel Wexselblatt; Eylon Yavin; Dan Gibson

doi:10.1002/anie.201300640

Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions

Ezequiel Wexselblatt
, Eylon Yavin
, Dan Gibson^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Losing ligands rapidly: Pt^IV complexes with haloacetato ligands can hydrolyze rapidly under biological conditions (pH7 and 37 °C, see scheme) and the rate increases with increasing pH value. Possible mechanisms for this hydrolysis are examined using H₂¹⁸O and ESI-MS analysis.

Original language	English
Pages (from-to)	6059-6062
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	23
DOIs	https://doi.org/10.1002/anie.201300640
State	Published - 3 Jun 2013

Keywords

haloacetato ligands
hydrolysis
platinum
prodrugs

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10.1002/anie.201300640

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title = "Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions",

abstract = "Losing ligands rapidly: PtIV complexes with haloacetato ligands can hydrolyze rapidly under biological conditions (pH7 and 37 °C, see scheme) and the rate increases with increasing pH value. Possible mechanisms for this hydrolysis are examined using H218O and ESI-MS analysis.",

keywords = "haloacetato ligands, hydrolysis, platinum, prodrugs",

author = "Ezequiel Wexselblatt and Eylon Yavin and Dan Gibson",

year = "2013",

month = jun,

day = "3",

doi = "10.1002/anie.201300640",

language = "אנגלית",

volume = "52",

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T1 - Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions

AU - Wexselblatt, Ezequiel

AU - Yavin, Eylon

AU - Gibson, Dan

PY - 2013/6/3

Y1 - 2013/6/3

N2 - Losing ligands rapidly: PtIV complexes with haloacetato ligands can hydrolyze rapidly under biological conditions (pH7 and 37 °C, see scheme) and the rate increases with increasing pH value. Possible mechanisms for this hydrolysis are examined using H218O and ESI-MS analysis.

AB - Losing ligands rapidly: PtIV complexes with haloacetato ligands can hydrolyze rapidly under biological conditions (pH7 and 37 °C, see scheme) and the rate increases with increasing pH value. Possible mechanisms for this hydrolysis are examined using H218O and ESI-MS analysis.

KW - haloacetato ligands

KW - hydrolysis

KW - platinum

KW - prodrugs

UR - https://www.scopus.com/pages/publications/84878392879

U2 - 10.1002/anie.201300640

DO - 10.1002/anie.201300640

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C2 - 23686723

AN - SCOPUS:84878392879

SN - 1433-7851

VL - 52

SP - 6059

EP - 6062

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 23

ER -

Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions

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Keywords

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