Plexiform neurofibroma tissue classification

L. Weizman*, L. Hoch, L. Ben Sira, L. Joskowicz, L. Pratt, S. Constantini, D. Ben Bashat

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Plexiform Neurofibroma (PN) is a major complication of NeuroFibromatosis-1 (NF1), a common genetic disease that involving the nervous system. PNs are peripheral nerve sheath tumors extending along the length of the nerve in various parts of the body. Treatment decision is based on tumor volume assessment using MRI, which is currently time consuming and error prone, with limited semi-automatic segmentation support. We present in this paper a new method for the segmentation and tumor mass quantification of PN from STIR MRI scans. The method starts with a user-based delineation of the tumor area in a single slice and automatically detects the PN lesions in the entire image based on the tumor connectivity. Experimental results on seven datasets yield a mean volume overlap difference of 25% as compared to manual segmentation by expert radiologist with a mean computation and interaction time of 12 minutes vs. over an hour for manual annotation. Since the user interaction in the segmentation process is minimal, our method has the potential to successfully become part of the clinical workflow.

Original languageAmerican English
Title of host publicationMedical Imaging 2011
Subtitle of host publicationImage Processing
StatePublished - 2011
EventMedical Imaging 2011: Image Processing - Lake Buena Vista, FL, United States
Duration: 14 Feb 201116 Feb 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2011: Image Processing
Country/TerritoryUnited States
CityLake Buena Vista, FL


  • Neurofibromatosis-1
  • Plexiform Neurofibromas
  • segmentation


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