Polarizability of G4-DNA observed by electrostatic force microscopy measurements

Hezy Cohen, Tomer Sapir, Natalia Borovok, Tatiana Molotsky, Rosa Di Felice, Alexander B. Kotlyar, Danny Porath*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


G4-DNA, a quadruple helical motif of stacked guanine tetrads, is stiffer and more resistant to surface forces than double-stranded DNA (dsDNA), yet it enables self-assembly. Therefore, it is more likely to enable charge transport upon deposition on hard supports. We report clear evidence of polarizability of long G4-DNA molecules measured by electrostatic force microscopy, while coadsorbed dsDNA molecules on mica are electrically silent. This is another sign that G4-DNA is potentially better than dsDNA as a conducting molecular wire.

Original languageAmerican English
Pages (from-to)981-986
Number of pages6
JournalNano Letters
Issue number4
StatePublished - Apr 2007


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