Polarizability of G4-DNA observed by electrostatic force microscopy measurements

Hezy Cohen; Tomer Sapir; Natalia Borovok; Tatiana Molotsky; Rosa Di Felice; Alexander B. Kotlyar; Danny Porath

doi:10.1021/nl070013b

Polarizability of G4-DNA observed by electrostatic force microscopy measurements

Hezy Cohen, Tomer Sapir, Natalia Borovok, Tatiana Molotsky, Rosa Di Felice, Alexander B. Kotlyar, Danny Porath^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

G4-DNA, a quadruple helical motif of stacked guanine tetrads, is stiffer and more resistant to surface forces than double-stranded DNA (dsDNA), yet it enables self-assembly. Therefore, it is more likely to enable charge transport upon deposition on hard supports. We report clear evidence of polarizability of long G4-DNA molecules measured by electrostatic force microscopy, while coadsorbed dsDNA molecules on mica are electrically silent. This is another sign that G4-DNA is potentially better than dsDNA as a conducting molecular wire.

Original language	English
Pages (from-to)	981-986
Number of pages	6
Journal	Nano Letters
Volume	7
Issue number	4
DOIs	https://doi.org/10.1021/nl070013b
State	Published - Apr 2007

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abstract = "G4-DNA, a quadruple helical motif of stacked guanine tetrads, is stiffer and more resistant to surface forces than double-stranded DNA (dsDNA), yet it enables self-assembly. Therefore, it is more likely to enable charge transport upon deposition on hard supports. We report clear evidence of polarizability of long G4-DNA molecules measured by electrostatic force microscopy, while coadsorbed dsDNA molecules on mica are electrically silent. This is another sign that G4-DNA is potentially better than dsDNA as a conducting molecular wire.",

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AU - Di Felice, Rosa

AU - Kotlyar, Alexander B.

AU - Porath, Danny

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AB - G4-DNA, a quadruple helical motif of stacked guanine tetrads, is stiffer and more resistant to surface forces than double-stranded DNA (dsDNA), yet it enables self-assembly. Therefore, it is more likely to enable charge transport upon deposition on hard supports. We report clear evidence of polarizability of long G4-DNA molecules measured by electrostatic force microscopy, while coadsorbed dsDNA molecules on mica are electrically silent. This is another sign that G4-DNA is potentially better than dsDNA as a conducting molecular wire.

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Polarizability of G4-DNA observed by electrostatic force microscopy measurements

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