Poly (anhydrides). 3. Poly (anhydrides) Based on Aliphatic—Aromatic Diacids

Abraham J. Domb; Carlos F. Gallardo; Robert Langer

doi:10.1021/ma00198a002

Poly (anhydrides). 3. Poly (anhydrides) Based on Aliphatic—Aromatic Diacids

Abraham J. Domb, Carlos F. Gallardo, Robert Langer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

Poly (anhydrides) containing aliphatic and aromatic moieties, poly(ω-(p-carboxyphenoxy)alkanoic anhydride), of the structure -(COC₆H₄0(CH2)„COO)_n- (x = 1, 4, and 7) were synthesized by either melt or solution polymerization with molecular weights of up to 44600. These polymers displayed a zero-order hydrolytic degradation profile for 2–10 weeks. The longer the length of the alkanoic chain, the longer the degradation rate. Stability studies under anhydrous conditions showed that these polymers were stable in solid state for over 6 months at 25 °C but underwent reversible self-depolymerization in chloroform solution.

Original language	English
Pages (from-to)	3200-3204
Number of pages	5
Journal	Macromolecules
Volume	22
Issue number	8
DOIs	https://doi.org/10.1021/ma00198a002
State	Published - 1 Aug 1989
Externally published	Yes

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title = "Poly (anhydrides). 3. Poly (anhydrides) Based on Aliphatic—Aromatic Diacids",

abstract = "Poly (anhydrides) containing aliphatic and aromatic moieties, poly(ω-(p-carboxyphenoxy)alkanoic anhydride), of the structure -(COC6H40(CH2)„COO)n- (x = 1, 4, and 7) were synthesized by either melt or solution polymerization with molecular weights of up to 44600. These polymers displayed a zero-order hydrolytic degradation profile for 2–10 weeks. The longer the length of the alkanoic chain, the longer the degradation rate. Stability studies under anhydrous conditions showed that these polymers were stable in solid state for over 6 months at 25 °C but underwent reversible self-depolymerization in chloroform solution.",

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year = "1989",

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AU - Gallardo, Carlos F.

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N2 - Poly (anhydrides) containing aliphatic and aromatic moieties, poly(ω-(p-carboxyphenoxy)alkanoic anhydride), of the structure -(COC6H40(CH2)„COO)n- (x = 1, 4, and 7) were synthesized by either melt or solution polymerization with molecular weights of up to 44600. These polymers displayed a zero-order hydrolytic degradation profile for 2–10 weeks. The longer the length of the alkanoic chain, the longer the degradation rate. Stability studies under anhydrous conditions showed that these polymers were stable in solid state for over 6 months at 25 °C but underwent reversible self-depolymerization in chloroform solution.

AB - Poly (anhydrides) containing aliphatic and aromatic moieties, poly(ω-(p-carboxyphenoxy)alkanoic anhydride), of the structure -(COC6H40(CH2)„COO)n- (x = 1, 4, and 7) were synthesized by either melt or solution polymerization with molecular weights of up to 44600. These polymers displayed a zero-order hydrolytic degradation profile for 2–10 weeks. The longer the length of the alkanoic chain, the longer the degradation rate. Stability studies under anhydrous conditions showed that these polymers were stable in solid state for over 6 months at 25 °C but underwent reversible self-depolymerization in chloroform solution.

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Poly (anhydrides). 3. Poly (anhydrides) Based on Aliphatic—Aromatic Diacids

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