TY - JOUR
T1 - Poly I-C induces early embryo loss in F344 rats
T2 - A potential role for NK cells
AU - Arad, Michal
AU - Atzil, Shir
AU - Shakhar, Keren
AU - Adoni, Anat
AU - Ben-Eliyahu, Shamgar
PY - 2005/7
Y1 - 2005/7
N2 - Problem: Natural killer (NK) cells were associated with first trimester embryo loss. The current study in the inbred F344 rat assessed the role of NK cells in mediating resorptions caused by poly I-C, a non-specific immuno stimulator. Method of study: On fifth day of gestation, rats were injected intraperitoneally with anti-NKR-P1 (1.5 mg/kg, i.p.) to deplete NK cells, and with mouse serum or saline to control for non-specific effects. Poly I-C (4 mg/kg, i.p.) or vehicle were administered 2 days later. Resorptions were assessed on day 13.5. Results: Poly I-C significantly elevated resorption rates, and anti-NKR-P1 abolished this effect. Body weight was reduced in all rats treated with poly I-C, including NK-depleted rats. This indicates the ability of NK-depleted rats to respond to poly I-C, yet to refrain from the resorption-promoting effects of poly I-C. Conclusions: This study suggests a role for NK cells in mediating poly I-C-induced resorptions.
AB - Problem: Natural killer (NK) cells were associated with first trimester embryo loss. The current study in the inbred F344 rat assessed the role of NK cells in mediating resorptions caused by poly I-C, a non-specific immuno stimulator. Method of study: On fifth day of gestation, rats were injected intraperitoneally with anti-NKR-P1 (1.5 mg/kg, i.p.) to deplete NK cells, and with mouse serum or saline to control for non-specific effects. Poly I-C (4 mg/kg, i.p.) or vehicle were administered 2 days later. Resorptions were assessed on day 13.5. Results: Poly I-C significantly elevated resorption rates, and anti-NKR-P1 abolished this effect. Body weight was reduced in all rats treated with poly I-C, including NK-depleted rats. This indicates the ability of NK-depleted rats to respond to poly I-C, yet to refrain from the resorption-promoting effects of poly I-C. Conclusions: This study suggests a role for NK cells in mediating poly I-C-induced resorptions.
KW - Anti-NKR-P1
KW - Natural killer cells
KW - Poly I-C
KW - Resorption
UR - http://www.scopus.com/inward/record.url?scp=21244434817&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0897.2005.00286.x
DO - 10.1111/j.1600-0897.2005.00286.x
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C2 - 15948772
AN - SCOPUS:21244434817
SN - 1046-7408
VL - 54
SP - 49
EP - 53
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
IS - 1
ER -