Abstract
The effect of transfection of NIH 3T3 cells by the human ras (c-Ha-ras-1) oncogene on uptake, interconversion, and excretion of polyamines was studied. Uptake and interconversion of spermidine were higher in the ras-transfected cells. Acetylpolyamines were excreted into the medium by the ras-transfected cells, whereas they were retained by NIH 3T3 cells. In addition to acetylpolyamines, some unknown polyamine conjugates occurred in the ras-transfected cells.
| Original language | English |
|---|---|
| Pages (from-to) | 3336-3340 |
| Number of pages | 5 |
| Journal | Cancer Research |
| Volume | 48 |
| Issue number | 12 |
| State | Published - 1988 |
