Polyamine Metabolism and Interconversion in NIH 3T3 and ras-transfected NIH 3T3 Cells

Rajbabu Pakala; Miriam Kreisel; Uriel Bachrach

Polyamine Metabolism and Interconversion in NIH 3T3 and ras-transfected NIH 3T3 Cells

Rajbabu Pakala
, Miriam Kreisel
, Uriel Bachrach^*

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The effect of transfection of NIH 3T3 cells by the human ras (c-Ha-ras-1) oncogene on uptake, interconversion, and excretion of polyamines was studied. Uptake and interconversion of spermidine were higher in the ras-transfected cells. Acetylpolyamines were excreted into the medium by the ras-transfected cells, whereas they were retained by NIH 3T3 cells. In addition to acetylpolyamines, some unknown polyamine conjugates occurred in the ras-transfected cells.

Original language	English
Pages (from-to)	3336-3340
Number of pages	5
Journal	Cancer Research
Volume	48
Issue number	12
State	Published - 1988

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title = "Polyamine Metabolism and Interconversion in NIH 3T3 and ras-transfected NIH 3T3 Cells",

abstract = "The effect of transfection of NIH 3T3 cells by the human ras (c-Ha-ras-1) oncogene on uptake, interconversion, and excretion of polyamines was studied. Uptake and interconversion of spermidine were higher in the ras-transfected cells. Acetylpolyamines were excreted into the medium by the ras-transfected cells, whereas they were retained by NIH 3T3 cells. In addition to acetylpolyamines, some unknown polyamine conjugates occurred in the ras-transfected cells.",

author = "Rajbabu Pakala and Miriam Kreisel and Uriel Bachrach",

year = "1988",

language = "אנגלית",

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publisher = "American Association for Cancer Research Inc.",

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AU - Pakala, Rajbabu

AU - Kreisel, Miriam

AU - Bachrach, Uriel

PY - 1988

Y1 - 1988

N2 - The effect of transfection of NIH 3T3 cells by the human ras (c-Ha-ras-1) oncogene on uptake, interconversion, and excretion of polyamines was studied. Uptake and interconversion of spermidine were higher in the ras-transfected cells. Acetylpolyamines were excreted into the medium by the ras-transfected cells, whereas they were retained by NIH 3T3 cells. In addition to acetylpolyamines, some unknown polyamine conjugates occurred in the ras-transfected cells.

AB - The effect of transfection of NIH 3T3 cells by the human ras (c-Ha-ras-1) oncogene on uptake, interconversion, and excretion of polyamines was studied. Uptake and interconversion of spermidine were higher in the ras-transfected cells. Acetylpolyamines were excreted into the medium by the ras-transfected cells, whereas they were retained by NIH 3T3 cells. In addition to acetylpolyamines, some unknown polyamine conjugates occurred in the ras-transfected cells.

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C2 - 3285993

AN - SCOPUS:0023893063

SN - 0008-5472

VL - 48

SP - 3336

EP - 3340

JO - Cancer Research

JF - Cancer Research

IS - 12

ER -

Polyamine Metabolism and Interconversion in NIH 3T3 and ras-transfected NIH 3T3 Cells

Abstract

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