TY - JOUR
T1 - Polyamines and neoplastic growth:stabilization of ornithine decarboxylase during transformation
AU - Bachrach, U.
PY - 1976/10/4
Y1 - 1976/10/4
N2 - Transformation of chick embryo fibroblasts by Rous sarcoma virus leads to the stabilization of ornithine decarboxylaes. A two-fold increase in the half-life of the enzyme is noted after infection with the wild type Schmidt-Ruppin, but not after infection with the temperature-sensitive mutant T5, under restrictive conditions. The half-life of the enzyme doubles soon after shifting the temperature of a RSV-T5 infected culture from 42° to 37° and after adding fresh medium to cultures of normal chick embryo fibroblasts at relative high densities.
AB - Transformation of chick embryo fibroblasts by Rous sarcoma virus leads to the stabilization of ornithine decarboxylaes. A two-fold increase in the half-life of the enzyme is noted after infection with the wild type Schmidt-Ruppin, but not after infection with the temperature-sensitive mutant T5, under restrictive conditions. The half-life of the enzyme doubles soon after shifting the temperature of a RSV-T5 infected culture from 42° to 37° and after adding fresh medium to cultures of normal chick embryo fibroblasts at relative high densities.
UR - http://www.scopus.com/inward/record.url?scp=0017190978&partnerID=8YFLogxK
U2 - 10.1016/S0006-291X(76)80232-X
DO - 10.1016/S0006-291X(76)80232-X
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C2 - 186053
AN - SCOPUS:0017190978
SN - 0006-291X
VL - 72
SP - 1008
EP - 1013
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -
