Polyamines and protein kinase II. Effect of polyamines on cyclic AMP - Dependent protein kinase from rat liver

Jacob Hochman; Aviva Katz; Uriel Bachrach

doi:10.1016/0024-3205(78)90002-4

Polyamines and protein kinase II. Effect of polyamines on cyclic AMP - Dependent protein kinase from rat liver

Jacob Hochman^*, Aviva Katz, Uriel Bachrach

^*Corresponding author for this work

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Abstract

The effect of polyamines on the activity of cAMP-dependent protein kinase from rat liver was determined. It has been shown that polyamines inactivate the enzyme in the decreasing order of activity: spermine > spermidine > putrescine. This effect is due to inhibition of the catalytic subunit. On the other hand, binding of cAMP to the regulatory subunit of the enzyme is not affected by polyamines. It is suggested that the inhibition of protein kinase by polyamines is a general phenomenon.

Original language	English
Pages (from-to)	1481-1484
Number of pages	4
Journal	Life Sciences
Volume	22
Issue number	17
DOIs	https://doi.org/10.1016/0024-3205(78)90002-4
State	Published - 1 May 1978

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abstract = "The effect of polyamines on the activity of cAMP-dependent protein kinase from rat liver was determined. It has been shown that polyamines inactivate the enzyme in the decreasing order of activity: spermine > spermidine > putrescine. This effect is due to inhibition of the catalytic subunit. On the other hand, binding of cAMP to the regulatory subunit of the enzyme is not affected by polyamines. It is suggested that the inhibition of protein kinase by polyamines is a general phenomenon.",

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AU - Hochman, Jacob

AU - Katz, Aviva

AU - Bachrach, Uriel

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N2 - The effect of polyamines on the activity of cAMP-dependent protein kinase from rat liver was determined. It has been shown that polyamines inactivate the enzyme in the decreasing order of activity: spermine > spermidine > putrescine. This effect is due to inhibition of the catalytic subunit. On the other hand, binding of cAMP to the regulatory subunit of the enzyme is not affected by polyamines. It is suggested that the inhibition of protein kinase by polyamines is a general phenomenon.

AB - The effect of polyamines on the activity of cAMP-dependent protein kinase from rat liver was determined. It has been shown that polyamines inactivate the enzyme in the decreasing order of activity: spermine > spermidine > putrescine. This effect is due to inhibition of the catalytic subunit. On the other hand, binding of cAMP to the regulatory subunit of the enzyme is not affected by polyamines. It is suggested that the inhibition of protein kinase by polyamines is a general phenomenon.

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Polyamines and protein kinase II. Effect of polyamines on cyclic AMP - Dependent protein kinase from rat liver

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