Polyamines: New cues in cellular signal transduction

Uriel Bachrach*, Yong Chun Wang, Amalia Tabib

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

114 Scopus citations


The naturally occurring polyamines putrescine, spermidine, and spermine are involved in signal transduction. This has been demonstrated by using inhibitors for polyamine biosynthesis (such as α-difluoromethylornithine) or adding polyamines to cultured cells. Different polyamines, preferentially activated protein kinases (tyrosine kinases and MAP kinases), stimulated the expression of nuclear protooncogenes (myc, jun, and fos).

Original languageAmerican English
Pages (from-to)106-109
Number of pages4
JournalNews in Physiological Sciences
Issue number3
StatePublished - Jun 2001


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