Poly(anhydride) administration in high doses in vivo: Studies of biocompatibility and toxicology

C. Laurencin, A. Domb, C. Morris, V. Brown, M. Chasin, R. McConnell, N. Lange, R. Langer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Poly(anhydrides) proposed for use as vehicles for controlled drug delivery were administered subcutaneously in Sprague‐Dawley rats at two dosage levels (800 mg/kg rat and 2400 mg/kg rat) for a period of eight weeks. Biocompatibility was assessed using a number of methods. Thirtysix clinical chemistry and hematology parameters were monitored throughout the study. Blood values were statistically analyzed for any possible effects due to the implanted polymer. After 8 weeks, rats were sacrificed and complete necropsies were performed. Histological evaluations of 33 organ sites including heart, lung, liver, kidney, and brain were performed. In addition, subcutaneous implant sites were excised and examined both grossly and microscopically. Results from evaluations of blood chemistry and hematology data, organ analyses and local implant site analyses overall demonstrated that the poly(anhydride) biomaterial possessed excellent in vivo biocompatibility.

Original languageEnglish
Pages (from-to)1463-1481
Number of pages19
JournalJournal of Biomedical Materials Research
Volume24
Issue number11
DOIs
StatePublished - Nov 1990
Externally publishedYes

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