TY - JOUR
T1 - Poly(anhydride) administration in high doses in vivo
T2 - Studies of biocompatibility and toxicology
AU - Laurencin, C.
AU - Domb, A.
AU - Morris, C.
AU - Brown, V.
AU - Chasin, M.
AU - McConnell, R.
AU - Lange, N.
AU - Langer, R.
PY - 1990/11
Y1 - 1990/11
N2 - Poly(anhydrides) proposed for use as vehicles for controlled drug delivery were administered subcutaneously in Sprague‐Dawley rats at two dosage levels (800 mg/kg rat and 2400 mg/kg rat) for a period of eight weeks. Biocompatibility was assessed using a number of methods. Thirtysix clinical chemistry and hematology parameters were monitored throughout the study. Blood values were statistically analyzed for any possible effects due to the implanted polymer. After 8 weeks, rats were sacrificed and complete necropsies were performed. Histological evaluations of 33 organ sites including heart, lung, liver, kidney, and brain were performed. In addition, subcutaneous implant sites were excised and examined both grossly and microscopically. Results from evaluations of blood chemistry and hematology data, organ analyses and local implant site analyses overall demonstrated that the poly(anhydride) biomaterial possessed excellent in vivo biocompatibility.
AB - Poly(anhydrides) proposed for use as vehicles for controlled drug delivery were administered subcutaneously in Sprague‐Dawley rats at two dosage levels (800 mg/kg rat and 2400 mg/kg rat) for a period of eight weeks. Biocompatibility was assessed using a number of methods. Thirtysix clinical chemistry and hematology parameters were monitored throughout the study. Blood values were statistically analyzed for any possible effects due to the implanted polymer. After 8 weeks, rats were sacrificed and complete necropsies were performed. Histological evaluations of 33 organ sites including heart, lung, liver, kidney, and brain were performed. In addition, subcutaneous implant sites were excised and examined both grossly and microscopically. Results from evaluations of blood chemistry and hematology data, organ analyses and local implant site analyses overall demonstrated that the poly(anhydride) biomaterial possessed excellent in vivo biocompatibility.
UR - http://www.scopus.com/inward/record.url?scp=0025514036&partnerID=8YFLogxK
U2 - 10.1002/jbm.820241105
DO - 10.1002/jbm.820241105
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C2 - 2279981
AN - SCOPUS:0025514036
SN - 0021-9304
VL - 24
SP - 1463
EP - 1481
JO - Journal of Biomedical Materials Research
JF - Journal of Biomedical Materials Research
IS - 11
ER -