Polyanhydrides

Muntimadugu Eameema; Lakshmi Sailaja Duvvuri; Wahid Khan; Abraham J. Domb

doi:10.1016/B978-0-12-396983-5.00010-7

Polyanhydrides

Muntimadugu Eameema^*, Lakshmi Sailaja Duvvuri, Wahid Khan, Abraham J. Domb

^*Corresponding author for this work

School of Pharmacy

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

16 Scopus citations

Abstract

Distinctive properties of polyanhydrides make them as a unique class of biodegradable polymers. Constant drug release rates are expected from these hydrophobic, surface-eroding polymers. Degradation of polymer can be altered easily by changing various parameters such as composition, crystallinity, molecular weight, and pH of the surrounding medium. Tremendous research in this class of polymers resulted in clinical use of few marketed products. Based on the usefulness of the polymer, this chapter briefly discusses the history of polyanhydrides and various classes that come under this category. It also focuses on synthesis methods, biodegradability, biocompatibility, and toxic issues of the polymer. Potential applications of polyanhydrides in drug delivery, vaccine delivery, and protein delivery are mentioned along with their controlled release applications.

Original language	English
Title of host publication	Natural and Synthetic Biomedical Polymers
Publisher	Elsevier Inc.
Pages	181-192
Number of pages	12
ISBN (Print)	9780123969835
DOIs	https://doi.org/10.1016/B978-0-12-396983-5.00010-7
State	Published - Jan 2014

Keywords

Biocompatability
Biodegradability
Polyanhydrides
Properties
Synthesis

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10.1016/B978-0-12-396983-5.00010-7

Cite this

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AU - Khan, Wahid

AU - Domb, Abraham J.

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AB - Distinctive properties of polyanhydrides make them as a unique class of biodegradable polymers. Constant drug release rates are expected from these hydrophobic, surface-eroding polymers. Degradation of polymer can be altered easily by changing various parameters such as composition, crystallinity, molecular weight, and pH of the surrounding medium. Tremendous research in this class of polymers resulted in clinical use of few marketed products. Based on the usefulness of the polymer, this chapter briefly discusses the history of polyanhydrides and various classes that come under this category. It also focuses on synthesis methods, biodegradability, biocompatibility, and toxic issues of the polymer. Potential applications of polyanhydrides in drug delivery, vaccine delivery, and protein delivery are mentioned along with their controlled release applications.

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KW - Properties

KW - Synthesis

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Polyanhydrides

Abstract

Keywords

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