Polybarbiturates

Menashe Tahan*, Naftali Lander, Albert Zilkha

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Several p‐vinylbenzyl malonates were synthesized and condensed with urea to form the corresponding 5‐p‐vinylbenzyl barbiturates, which were polymerized. The gross behavioral changes observed on intraperitoneal (i.p.) administration of the polybarbiturates to mice were compared with those caused by the monomers. The polymers were less toxic but had weaker sedative effects than their respective monomers, and they did not exhibit any prolongation of activity.

Original languageEnglish
Pages (from-to)835-840
Number of pages6
JournalIsrael Journal of Chemistry
Volume11
Issue number6
DOIs
StatePublished - 1973

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