TY - JOUR
T1 - Polydepsipeptides II
T2 - Synthesis and Preliminary Conformational Studies of an Alternating α‐Amino and α‐Hydroxy Acid Polymer
AU - Goodman, Murray
AU - Gilon, Chaim
AU - Palumbo, Manlio
AU - Ingwall, Richard T.
PY - 1974
Y1 - 1974
N2 - An alternating high‐molecular‐weight polymer of L‐valine and L‐lactic acid was synthesized in the solid state. Results from circular dichroism (CD) and nuclear magnetic resonance (NMR) spectra indicate that these polymers are helical in helicogenic solvents such as chloroform and trifluoroethanol (TFE). The conformational analysis is extended to include semi‐empirical energy calculations for alternating α‐amino and α‐hydroxy acid polymers. Preliminary calculations based on depsipeptides from L‐alanine and L‐lactic acid are presented.
AB - An alternating high‐molecular‐weight polymer of L‐valine and L‐lactic acid was synthesized in the solid state. Results from circular dichroism (CD) and nuclear magnetic resonance (NMR) spectra indicate that these polymers are helical in helicogenic solvents such as chloroform and trifluoroethanol (TFE). The conformational analysis is extended to include semi‐empirical energy calculations for alternating α‐amino and α‐hydroxy acid polymers. Preliminary calculations based on depsipeptides from L‐alanine and L‐lactic acid are presented.
UR - http://www.scopus.com/inward/record.url?scp=84987311121&partnerID=8YFLogxK
U2 - 10.1002/ijch.197400008
DO - 10.1002/ijch.197400008
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AN - SCOPUS:84987311121
SN - 0021-2148
VL - 12
SP - 67
EP - 77
JO - Israel Journal of Chemistry
JF - Israel Journal of Chemistry
IS - 1-2
ER -