Poly(ethylene glycol)-poly(epsilon-caprolactone) block oligomers as injectable materials

A. Sosnik; D. Cohn

doi:10.1016/j.polymer.2003.09.012

Poly(ethylene glycol)-poly(epsilon-caprolactone) block oligomers as injectable materials

A. Sosnik^*
, D. Cohn

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

A family of segmented low MW poly(ethylene glycol)-poly(epsilon-caprolactone) (PEG-PCL) oligomers was synthesized by reacting PCL-based macrodiisocyanates and diblocks comprising MPEG and PCL short segments. The oligomers have the following general structure: MPEG350-(CL)_n-HDI-PCL530-HDI-(CL)_n-MPEG350. The composition of the oligomers and their molecular weight was determined by ¹H and ¹³C-NMR, FT-IR and GPC. Depending on the length of the (CL)_n block, soft waxes to hard solids were produced. The isothermal crystallization process was performed at various temperatures and investigated by DSC, FT-IR and WAXS, while the mechanical behavior was determined using a compression test. All the oligomers investigated were able to crystallize at low temperatures (4 and 25 °C), while at body temperature, only oligomers comprising longer (CL)_n blocks (n = 5 and above), were able to crystallize.

Original language	English
Pages (from-to)	7033-7042
Number of pages	10
Journal	Polymer
Volume	44
Issue number	23
DOIs	https://doi.org/10.1016/j.polymer.2003.09.012
State	Published - 17 Oct 2003

Keywords

Crystallization
Injectable materials
PCL-PEG block oligomers

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10.1016/j.polymer.2003.09.012

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title = "Poly(ethylene glycol)-poly(epsilon-caprolactone) block oligomers as injectable materials",

abstract = "A family of segmented low MW poly(ethylene glycol)-poly(epsilon-caprolactone) (PEG-PCL) oligomers was synthesized by reacting PCL-based macrodiisocyanates and diblocks comprising MPEG and PCL short segments. The oligomers have the following general structure: MPEG350-(CL)n-HDI-PCL530-HDI-(CL)n-MPEG350. The composition of the oligomers and their molecular weight was determined by 1H and 13C-NMR, FT-IR and GPC. Depending on the length of the (CL)n block, soft waxes to hard solids were produced. The isothermal crystallization process was performed at various temperatures and investigated by DSC, FT-IR and WAXS, while the mechanical behavior was determined using a compression test. All the oligomers investigated were able to crystallize at low temperatures (4 and 25 °C), while at body temperature, only oligomers comprising longer (CL)n blocks (n = 5 and above), were able to crystallize.",

keywords = "Crystallization, Injectable materials, PCL-PEG block oligomers",

author = "A. Sosnik and D. Cohn",

year = "2003",

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doi = "10.1016/j.polymer.2003.09.012",

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T1 - Poly(ethylene glycol)-poly(epsilon-caprolactone) block oligomers as injectable materials

AU - Sosnik, A.

AU - Cohn, D.

PY - 2003/10/17

Y1 - 2003/10/17

N2 - A family of segmented low MW poly(ethylene glycol)-poly(epsilon-caprolactone) (PEG-PCL) oligomers was synthesized by reacting PCL-based macrodiisocyanates and diblocks comprising MPEG and PCL short segments. The oligomers have the following general structure: MPEG350-(CL)n-HDI-PCL530-HDI-(CL)n-MPEG350. The composition of the oligomers and their molecular weight was determined by 1H and 13C-NMR, FT-IR and GPC. Depending on the length of the (CL)n block, soft waxes to hard solids were produced. The isothermal crystallization process was performed at various temperatures and investigated by DSC, FT-IR and WAXS, while the mechanical behavior was determined using a compression test. All the oligomers investigated were able to crystallize at low temperatures (4 and 25 °C), while at body temperature, only oligomers comprising longer (CL)n blocks (n = 5 and above), were able to crystallize.

AB - A family of segmented low MW poly(ethylene glycol)-poly(epsilon-caprolactone) (PEG-PCL) oligomers was synthesized by reacting PCL-based macrodiisocyanates and diblocks comprising MPEG and PCL short segments. The oligomers have the following general structure: MPEG350-(CL)n-HDI-PCL530-HDI-(CL)n-MPEG350. The composition of the oligomers and their molecular weight was determined by 1H and 13C-NMR, FT-IR and GPC. Depending on the length of the (CL)n block, soft waxes to hard solids were produced. The isothermal crystallization process was performed at various temperatures and investigated by DSC, FT-IR and WAXS, while the mechanical behavior was determined using a compression test. All the oligomers investigated were able to crystallize at low temperatures (4 and 25 °C), while at body temperature, only oligomers comprising longer (CL)n blocks (n = 5 and above), were able to crystallize.

KW - Crystallization

KW - Injectable materials

KW - PCL-PEG block oligomers

UR - https://www.scopus.com/pages/publications/0141919789

U2 - 10.1016/j.polymer.2003.09.012

DO - 10.1016/j.polymer.2003.09.012

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AN - SCOPUS:0141919789

SN - 0032-3861

VL - 44

SP - 7033

EP - 7042

JO - Polymer

JF - Polymer

IS - 23

ER -

Poly(ethylene glycol)-poly(epsilon-caprolactone) block oligomers as injectable materials

Abstract

Keywords

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