Polygenic embryo screening: Four clinical considerations warrant further attention

S. Pereira; S. Carmi; G. Altarescu; J. Austin; D. Barlevy; A. Hershlag; E. Juengst; K. Kostick-Quenet; E. Kovanci; R. B. Lathi; M. Mukherjee; I. Van Den Veyver; O. Zuk; G. Lázaro-Muñoz; T. Lencz

doi:10.1093/humrep/deac110

Polygenic embryo screening: Four clinical considerations warrant further attention

S. Pereira^*, S. Carmi, G. Altarescu, J. Austin, D. Barlevy, A. Hershlag, E. Juengst, K. Kostick-Quenet, E. Kovanci, R. B. Lathi, M. Mukherjee, I. Van Den Veyver, O. Zuk, G. Lázaro-Muñoz, T. Lencz

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Recent advances in developing polygenic scores have made it possible to screen embryos for common, complex conditions and traits. Polygenic embryo screening (PES) is currently offered commercially, and though there has been much recent media and academic coverage, reproductive specialists' points of view have not yet been prominent in these discussions. We convened a roundtable of multidisciplinary experts, including reproductive specialists to discuss PES and its implications. In this Opinion, we describe four clinically relevant issues associated with the use of PES that have not yet been discussed in the literature and warrant consideration.

Original language	English
Pages (from-to)	1375-1378
Number of pages	4
Journal	Human Reproduction
Volume	37
Issue number	7
DOIs	https://doi.org/10.1093/humrep/deac110
State	Published - 1 Jul 2022

Bibliographical note

Publisher Copyright:
© 2022 The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. All rights reserved.

Keywords

PRS
embryo screening
genetic screening
genomic risk scores
polygenic embryo screening
polygenic risk scores
trait screening

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10.1093/humrep/deac110

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Pereira, S., Carmi, S., Altarescu, G., Austin, J., Barlevy, D., Hershlag, A., Juengst, E., Kostick-Quenet, K., Kovanci, E., Lathi, R. B., Mukherjee, M., Van Den Veyver, I., Zuk, O., Lázaro-Muñoz, G., & Lencz, T. (2022). Polygenic embryo screening: Four clinical considerations warrant further attention. Human Reproduction, 37(7), 1375-1378. https://doi.org/10.1093/humrep/deac110

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Pereira, S, Carmi, S, Altarescu, G, Austin, J, Barlevy, D, Hershlag, A, Juengst, E, Kostick-Quenet, K, Kovanci, E, Lathi, RB, Mukherjee, M, Van Den Veyver, I, Zuk, O, Lázaro-Muñoz, G & Lencz, T 2022, 'Polygenic embryo screening: Four clinical considerations warrant further attention', Human Reproduction, vol. 37, no. 7, pp. 1375-1378. https://doi.org/10.1093/humrep/deac110

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AU - Hershlag, A.

AU - Juengst, E.

AU - Kostick-Quenet, K.

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AU - Lathi, R. B.

AU - Mukherjee, M.

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Polygenic embryo screening: Four clinical considerations warrant further attention

Abstract

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Keywords

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