Polymer carriers for drug delivery in tissue engineering

Marina Sokolsky-Papkov; Kapil Agashi; Andrew Olaye; Kevin Shakesheff; Abraham J. Domb

doi:10.1016/j.addr.2007.04.001

Polymer carriers for drug delivery in tissue engineering

Marina Sokolsky-Papkov, Kapil Agashi, Andrew Olaye, Kevin Shakesheff, Abraham J. Domb^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

413 Scopus citations

Abstract

Growing demand for tissues and organs for transplantation and the inability to meet this need using by autogeneic (from the host) or allogeneic (from the same species) sources has led to the rapid development of tissue engineering as an alternative. Tissue engineering aims to replace or facilitate the regrowth of damaged or diseased tissue by applying a combination of biomaterials, cells and bioactive molecules. This review focuses on synthetic polymers that have been used for tissue growth scaffold fabrication and their applications in both cell and extracellular matrix support and controlling the release of cell growth and differentiation supporting drugs.

Original language	English
Pages (from-to)	187-206
Number of pages	20
Journal	Advanced Drug Delivery Reviews
Volume	59
Issue number	4-5
DOIs	https://doi.org/10.1016/j.addr.2007.04.001
State	Published - 30 May 2007

Keywords

Collagen blends
Polyester
Scaffold
Scaffold fabrication

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AU - Agashi, Kapil

AU - Olaye, Andrew

AU - Shakesheff, Kevin

AU - Domb, Abraham J.

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AB - Growing demand for tissues and organs for transplantation and the inability to meet this need using by autogeneic (from the host) or allogeneic (from the same species) sources has led to the rapid development of tissue engineering as an alternative. Tissue engineering aims to replace or facilitate the regrowth of damaged or diseased tissue by applying a combination of biomaterials, cells and bioactive molecules. This review focuses on synthetic polymers that have been used for tissue growth scaffold fabrication and their applications in both cell and extracellular matrix support and controlling the release of cell growth and differentiation supporting drugs.

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KW - Polyester

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KW - Scaffold fabrication

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Polymer carriers for drug delivery in tissue engineering

Abstract

Keywords

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