TY - JOUR
T1 - Polysaccharide-Based Conjugates for Biomedical Applications
AU - Basu, Arijit
AU - Kunduru, Konda Reddy
AU - Abtew, Ester
AU - Domb, Abraham J.
N1 - Publisher Copyright:
© 2015 American Chemical Society.
PY - 2015/8/19
Y1 - 2015/8/19
N2 - Polysaccharides contain different functional groups (such as hydroxyl, amino, carboxylic acid, aldehydes) that make them ideal for conjugation. They are biodegradable, biocompatible, and hydrophilic. Polysaccharide conjugates have been used in drug, gene, and macromolecule delivery, tissue engineering, and other biomedical applications. Polysaccharide conjugates have also been used primarily for solubilization and controlled release of hydrophobic moieties. The advent of nanotechnology, gene therapy, and tissue engineering influenced the way these conjugates are now used. Modern day conjugates are modulated to be thermoresponsive, pH-responsive, photoresponsive, or target-specific (receptor mediated targeting). This Review briefly introduces different polysaccharides followed by different synthetic strategies used for conjugation; finally, recent applications were compiled.
AB - Polysaccharides contain different functional groups (such as hydroxyl, amino, carboxylic acid, aldehydes) that make them ideal for conjugation. They are biodegradable, biocompatible, and hydrophilic. Polysaccharide conjugates have been used in drug, gene, and macromolecule delivery, tissue engineering, and other biomedical applications. Polysaccharide conjugates have also been used primarily for solubilization and controlled release of hydrophobic moieties. The advent of nanotechnology, gene therapy, and tissue engineering influenced the way these conjugates are now used. Modern day conjugates are modulated to be thermoresponsive, pH-responsive, photoresponsive, or target-specific (receptor mediated targeting). This Review briefly introduces different polysaccharides followed by different synthetic strategies used for conjugation; finally, recent applications were compiled.
UR - http://www.scopus.com/inward/record.url?scp=84939817023&partnerID=8YFLogxK
U2 - 10.1021/acs.bioconjchem.5b00242
DO - 10.1021/acs.bioconjchem.5b00242
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C2 - 26106905
AN - SCOPUS:84939817023
SN - 1043-1802
VL - 26
SP - 1396
EP - 1412
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
IS - 8
ER -