Poly(sebacic acid-co-ricinoleic acid) biodegradable carrier for delivery of tamsulosin hydrochloride

Ehud Havivi, Shimon Farber, Abraham J. Domb*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Polyesteranhydrides synthesized by the transesterification of ricinoleic acid and sebacic acid followed by anhydride polymerization were examined as potential controlled delivery carrier for tamsulosin. Polymers containing 70% ricinoleic acid are liquid at body temperature and semisolid at room temperature. It was found that upon addition of the liquid polymer to water it solidifies to form a stable semisolid polymer. Tamsulosin hydrochloride (TAM), a highly selective α1A-adrenoreceptor antagonist that has been used for the treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH), was incorporated in the polymers (2-20% w/w) and its release in buffer solution was monitored. TAM was released for over 24 days while the polymer carrier was being degraded. Hydrolysis of formulations was studied by monitoring the weight loss of the samples and the changes in the polymer molecular weight. TAM formulations stability in p(SA-RA) 30:70 under different temperatures was evaluated. The release rate of the drug from polymer was found to be affected by drug content: the higher the content, the faster was the release. Also, hydrolysis of formulation containing tamsulosin was faster due to the hydrophility of the drug. The drug formulation was found to be stable for a period of 6 months. Moreover, after subcutaneously injection into mice, the drug-loaded formulation becomes into gel and remains in the site of the injection. To conclude, Poly(sebacic acid-co-ricinoleic-acid) containing ≥ 70% ricinoleic acid are injectable biodegradable polymers and are suitable candidates for the delivery of TAM for long acting therapy.

Original languageEnglish
Pages (from-to)114-118
Number of pages5
JournalPolymers for Advanced Technologies
Volume22
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • Benign prostatic hyperplasia
  • Biodegradable polymer
  • Controlled drug delivery
  • Ricinoleic acid
  • Sebacic acid
  • Tamsulosin

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